ArticleThe EMBO journal2022
A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component.
Article in The EMBO journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- 'Candidatus Liberibacter asiaticus' secretory protein SDE5640 activates host autophagy dependent on PSMD10 to mediate PBA1 degradation.The Plant journal : for cell and molecular biology · 2026Article
- The BTB/POZ-MATH Protein ZmBPM1 Interacts With Autophagy-related Protein ZmATG6 and Modulates the NLR Protein Rp1-D21-Mediated Defense Response in Maize.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Selective Autophagy Receptor CsNBR1 Confers Citrus Huanglongbing Resistance by Degrading 'Candidatus Liberibacter Asiaticus' Virulence Effectors.Molecular plant pathology · 2026Article
- Xanthomonas Type III Effector XopN Targets Scaffold Protein OsRACK1B to Suppress Rice Immunity.Molecular plant pathology · 2026Article
- NBR1-Mediated Selective Autophagy in Plant Development and Stress Responses.Plants (Basel, Switzerland) · 2026Review
- Bacteria use P-body condensates to attenuate host translation during infection.Science advances · 2026Article
- A Bacterial Effector Hijacks NBR1 to Modulate Both Autophagy and Ubiquitination-Mediated Degradation That Promotes Bacterial Infection.Plant biotechnology journal · 2026Article
- The diverse roles of host membranes in plant-microbe interactions.PLoS pathogens · 2026Article
- An In Vitro Ubiquitination Assay to Study Phytoplasmal Effector Function.Methods in molecular biology (Clifton, N.J.) · 2026Article
- MDM2-P53-V-ATPases axis driven by dehydroevodiamine to fight intracellular bacterial infection.Communications biology · 2025Article
- Vacuolar sorting receptors coordinate lytic vacuolar and autophagic transport for plant effector-triggered immunity.Nature plants · 2025Article
- Aphid effectors suppress plant immunity via recruiting defense proteins to processing bodies.Science advances · 2025Article
- A bacterial type III effector hijacks plant ubiquitin proteases to evade degradation.PLoS pathogens · 2025Article
- Autophagy and Bacterial infections.Autophagy reports · 2025Review
- A bacterial effector cleaves RIN4 to allow the dimerization and activation of its recognizing NLR.Plant physiology · 2024Article
- XopM, An FFAT Motif-Containing Type III Effector Protein From Xanthomonas, Suppresses MTI Responses at the Plant Plasma Membrane.Molecular plant pathology · 2024Article
- Erasing marks: Functions of plant deubiquitylating enzymes in modulating the ubiquitin code.The Plant cell · 2024Review
- Protein degrons and degradation: Exploring substrate recognition and pathway selection in plants.The Plant cell · 2024Review
- Comparative transcriptomics reveals a highly polymorphic Xanthomonas HrpG virulence regulon.BMC genomics · 2024Article
- An Update on the Study of the Molecular Mechanisms Involved in Autophagy during Bacterial Pathogenesis.Biomedicines · 2024Review
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Beyond its role in cellular homeostasis, autophagy plays anti- and promicrobial roles in host-microbe interactions, both in animals and plants. One prominent role of antimicrobial autophagy is to degrade intracellular pathogens or microbial molecules, in a process termed xenophagy. Consequently, microbes evolved mechanisms to hijack or modulate autophagy to escape elimination. Although well-described in animals, the extent to which xenophagy contributes to plant-bacteria interactions remains unknown. Here, we provide evidence that Xanthomonas campestris pv. vesicatoria (Xcv) suppresses host autophagy by utilizing type-III effector XopL. XopL interacts with and degrades the autophagy component SH3P2 via its E3 ligase activity to promote infection. Intriguingly, XopL is targeted for degradation by defense-related selective autophagy mediated by NBR1/Joka2, revealing a complex antagonistic interplay between XopL and the host autophagy machinery. Our results implicate plant antimicrobial autophagy in the depletion of a bacterial virulence factor and unravel an unprecedented pathogen strategy to counteract defense-related autophagy in plant-bacteria interactions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.