Evidence map›Paper›PMID 35620794›Full record

ArticleMaterials today. Bio2022

Bioactive cytomembrane@poly(citrate-peptide)-miRNA365 nanoplatform with immune escape and homologous targeting for colon cancer therapy.

Long Zhang, Wan Zhang, Hang Peng, Tianli Shen, Min Wang, Meng Luo, Xiaoyan Qu, Fengyi Qu, Wenguang Liu, Bo Lei and 1 more

Open access · goldAbstract read
In one paragraph

Article in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Long ZhangDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Wan ZhangThe First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, China.
Hang PengThe First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, China.
Tianli ShenThe First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, China.
Min WangFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China.
Meng LuoFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China.
Xiaoyan QuFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China.
Fengyi QuThe First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, 710061, China.
Wenguang LiuFrontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710054, China.
Bo LeiDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Shuanying YangDepartment of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
First Affiliated Hospital of Xi'an Jiaotong University · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CNXi'an Honghui Hospital · CNXi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colon cancer is one of the most common gastrointestinal tumors in the world. Currently, the commonly used methods such as radiotherapy, chemotherapy and drug treatments are often ineffective and have significant side effects. Here we developed a safe and efficient biomaterials based anti-tumor nanoplatform (M@NPs/miR365), which was formed with poly (citrate-peptide) (PCP), miRNA365 mimic and MC38 cancer cell membrane (M). PCP could efficiently deliver miR365 mimic into MC38 cancer cells, promote the apoptosis of MC38 tumor cells and regulate the expression of Bcl2 and Ki67

Indexed as

Bioactive biomaterialsColon cancer therapyGene deliveryPolycitratePseudotumor cell

Identifiers

PMID35620794
PMCPMC9127421
OpenAlexW4280560680

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.