Evidence map›Paper›PMID 35620769›Full record

ArticleCritical care explorations2022

Surfactant Protein D Influences Mortality During Abdominal Sepsis by Facilitating

Jack Varon, Antonio Arciniegas Rubio, Diana Amador-Munoz, Alexis Corcoran, Joseph A DeCorte, Colleen Isabelle, Miguel Pinilla Vera, Katherine Walker, Luke Brown, Manuela Cernadas and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care explorations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 3 institutions in 2 countries.

Jack VaronDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Antonio Arciniegas RubioDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Diana Amador-MunozDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Alexis CorcoranDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Joseph A DeCorteDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Colleen IsabelleDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Miguel Pinilla VeraDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Katherine WalkerDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Luke BrownDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Manuela CernadasDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Lynn BryDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.
Haopu YangDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA.
Georgios D KitsiosDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA.
Bryan J McVerryDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA.
Alison MorrisDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center, Pittsburgh, PA.
Hyunwook LeeDivision of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.
Judie HowrylakPulmonary, Allergy and Critical Care Division, Penn State Milton S. Hershey Medical Center, Hershey, PA.
Joshua A EnglertDivision of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, OH.
Rebecca M BaronDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA.
Brigham and Women's Hospital · USUniversity of Pittsburgh Medical Center · USThe Ohio State University Wexner Medical Center · US

Funding

Therapeutic modulation of zinc for lung injury and mechanobiologyR01HL142093 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BARON, REBECCA M, TSCHUMPERLIN, DANIEL J. · 2019 to 2022
$2.8M
MicroRNA-181b and SepsisR01GM115605 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI BARON, REBECCA M, FEINBERG, MARK W · 2015 to 2018
$1.8M
Role of mTORC1 in ventilator induced lung injuryK08GM102695 · NIGMS · OHIO STATE UNIVERSITY · PI ENGLERT, JOSHUA A · 2013 to 2017
$998k
NHLBI NIH HHS R01 HL142093NIGMS NIH HHS K08 GM102695NIGMS NIH HHS R01 GM115605
6 · The paper itself

Abstract

Determine the role of surfactant protein D (SPD) in sepsis.

designMurine in vivo study.

settingResearch laboratory at an academic medical center. PATIENTS: SPD knockout (SPD

interventionsSPD MEASUREMENTS AND MAIN

resultsSPD

conclusionsEnteral SPD exacerbates mortality after CLP by facilitating colonization of the mouse gut with

Indexed as

cecal ligation and puncturecritical illnessEscherichia colisepsissurfactant protein D

Identifiers

PMID35620769
PMCPMC9119639
OpenAlexW4280512889

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.