Evidence map›Paper›PMID 35620703›Full record

ReviewJID innovations : skin science from molecules to population health2022

Cutaneous Squamous Cell Carcinoma Arising in Immunosuppressed Patients: A Systematic Review of Tumor Profiling Studies.

Elliot D Blue, S Caleb Freeman, Marissa B Lobl, Dillon D Clarey, Rose L Fredrick, Ashley Wysong, Melodi Javid Whitley

Open access · goldAbstract readReview
In one paragraph

Review in JID innovations : skin science from molecules to population health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Interventions After First Post-Transplant Cutaneous Squamous Cell Carcinoma: A Proposed Decision Framework.Transplant international : official journal of the European Society for Organ Transplantation · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Elliot D BlueDepartment of Dermatology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
S Caleb FreemanDepartment of Dermatology, Oregon Health & Science University, Portland, Oregon, USA.
Marissa B LoblCollege of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Dillon D ClareyDepartment of Dermatology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Rose L FredrickLibrary Services, Creighton University, Omaha, Nebraska.
Ashley WysongDepartment of Dermatology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Melodi Javid WhitleyDepartment of Dermatology, University of Nebraska Medical Center, Omaha, Nebraska, USA.
University of Nebraska Medical Center · USCreighton University · USOregon Health & Science University · US

Funding

Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6M
Duke-UNC Chapel Hill Immunotherapy Training GrantT32CA211056 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHAO, NELSON J., SERODY, JONATHAN S. · 2017 to 2021
$2.2M
NCI NIH HHS T32 CA211056NIGMS NIH HHS T32 GM145449
6 · The paper itself

Abstract

As solid organ transplantation becomes more prevalent, more individuals are living as members of the immunosuppressed population with an elevated risk for cutaneous squamous cell carcinoma (cSCC). Although great progress has been made in understanding the pathogenesis of cSCC in general, little is known about the drivers of tumorigenesis in immunosuppressed patients and organ-transplant recipients, specifically. This systematic review sought to synthesize information regarding the genetic and epigenetic alterations as well as changes in protein and mRNA expression that place this growing population at risk for cSCC, influence treatment response, and promote tumor aggressiveness. This review will provide investigators with a framework to identify future areas of investigation and clinicians with additional insight into how to best manage these patients.

Indexed as

6-TG, 6-thioguanineAZA, azathioprineCNI, calcineurin inhibitorCsA, cyclosporinecSCC, cutaneous squamous cell carcinomahBD, human β-defensinICP, immunocompetent patientISP, immunosuppressed patientmiRNA, microRNANMSC, nonmelanoma skin cancerOTR, organ-transplant recipientp-Smad, phosphorylated SmadRTR, renal transplant recipientSCC, squamous cell carcinomaSTAT, signal transducer and activator of transcriptionTAK1, TGFβ-activated kinase 1VNO, voriconazole-N-oxide

Identifiers

PMID35620703
PMCPMC9127418
OpenAlexW4221076306

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.