Evidence map›Paper›PMID 35620577›Full record

ArticleOxidative medicine and cellular longevity2022

Effects of Genistein and Exercise Training on Brain Damage Induced by a High-Fat High-Sucrose Diet in Female C57BL/6 Mice.

Rongzi Li, Xiaowen Ding, Thangiah Geetha, Moni Fadamiro, Chaheyla R St Aubin, Minsub Shim, Layla Al-Nakkash, Tom L Broderick, Jeganathan Ramesh Babu

Open access · hybridAbstract read
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In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Rongzi LiDepartment of Nutrition, Dietetics, And Hospitality Management, Auburn University, AL 36849, USA.
Xiaowen DingDepartment of Nutrition, Dietetics, And Hospitality Management, Auburn University, AL 36849, USA.ORCID https://orcid.org/0000-0001-9714-629X
Thangiah GeethaDepartment of Nutrition, Dietetics, And Hospitality Management, Auburn University, AL 36849, USA.
Moni FadamiroDepartment of Nutrition, Dietetics, And Hospitality Management, Auburn University, AL 36849, USA.
Chaheyla R St AubinDepartment of Physiology, College of Graduate Studies, Midwestern University, AZ 85308, USA.
Minsub ShimDepartment of Biochemistry, College of Graduate Studies, Midwestern University, AZ 85308, USA.
Layla Al-NakkashDepartment of Physiology, College of Graduate Studies, Midwestern University, AZ 85308, USA.ORCID https://orcid.org/0000-0001-9309-6213
Tom L BroderickDepartment of Physiology, Laboratory of Diabetes and Exercise Metabolism, College of Graduate Studies, Midwestern University, AZ 85308, USA.ORCID https://orcid.org/0000-0002-5179-3712
Jeganathan Ramesh BabuDepartment of Nutrition, Dietetics, And Hospitality Management, Auburn University, AL 36849, USA.ORCID https://orcid.org/0000-0002-3719-932X
Auburn University · USMidwestern University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent decades, a shift in the nutritional landscape to the Western-style diet has led to an unprecedented rise in the prevalence of obesity and neurodegenerative diseases. Consumption of a healthy diet and engaging in regular physical activity represents safe and affordable approaches known to mitigate the adverse consequences of the Western diet. We examined whether genistein treatment, exercise training, and a combination treatment (genistein and exercise training) mitigated the effects of a Western diet-induced by high-fat, high-sugar (HFHS) in brain of female mice. HFHS increased the amyloid-beta (A

Indexed as

Brain InjuriesGenisteinAmyloid beta-PeptidesAnimalsBrainBrain-Derived Neurotrophic FactorDiet, High-FatFemaleMiceMice, Inbred C57BLRatsSucroseTamoxifenAmyloid beta-PeptidesBrain-Derived Neurotrophic FactorGenisteinSucroseTamoxifen

Identifiers

PMID35620577
PMCPMC9129997
OpenAlexW4280647441

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.