Evidence map›Paper›PMID 35620287›Full record

ArticleFrontiers in pharmacology2022

Antidepressants Fluoxetine Mediates Endoplasmic Reticulum Stress and Autophagy of Non-Small Cell Lung Cancer Cells Through the ATF4-AKT-mTOR Signaling Pathway.

Shali Shao, Xibing Zhuang, Lin Zhang, Tiankui Qiao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Endoplasmic reticulum stress in non-small cell lung cancer.American journal of cancer research · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Repurposed Drugs in Gastric Cancer.Molecules (Basel, Switzerland) · 2022
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Shali ShaoCenter for Tumor Diagnosis and Therapy, Jinshan Hospital, Fudan University, Shanghai, China.
Xibing ZhuangCenter for Tumor Diagnosis and Therapy, Jinshan Hospital, Fudan University, Shanghai, China.
Lin ZhangDepartment of Emergency and Critical Care Medicine, Jinshan Hospital, Fudan University, Shanghai, China.
Tiankui QiaoCenter for Tumor Diagnosis and Therapy, Jinshan Hospital, Fudan University, Shanghai, China.
Jinshan Hospital of Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fluoxetine, one of the latest clinical antidepressants, is reported to have the anti-proliferative effect on cancer cells

Indexed as

ATF4-AKT-mTOR signaling pathwayautophagyendoplasmic reticulum stressfluoxetinenon-small cell lung cancer

Identifiers

PMID35620287
PMCPMC9127500
OpenAlexW4280506138

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.