Evidence map›Paper›PMID 35620269›Full record

ArticleDisease markers2022

Effect and Mechanism of Endothelin Receptor A Inhibitor BQ-123 Combined with Electroacupuncture on Tibia Cancer Pain in Rats.

Jie Tang, Zhilu Sun, Yan Wang, Jing Liu, Shuai Wang, Xilian Wang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease markers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jie TangThe First Affiliated Hospital, Department of Pain, Hengyang Medical School, University of South China, 421001, China.ORCID https://orcid.org/0000-0002-0527-1657
Zhilu SunThe First Affiliated Hospital, Department of Emergency, Hengyang Medical School, University of South China, 421001, China.ORCID https://orcid.org/0000-0002-2483-5024
Yan WangThe First Affiliated Hospital, Department of Pathology, Hengyang Medical School, University of South China, 421001, China.ORCID https://orcid.org/0000-0003-1758-0083
Jing LiuThe First Affiliated Hospital, Department of Rehabilitation, Hengyang Medical School, University of South China, 421001, China.ORCID https://orcid.org/0000-0003-3433-364X
Shuai WangThe First Affiliated Hospital, Department of Hand Foot Surgery, Hengyang Medical School, University of South China, 421001, China.ORCID https://orcid.org/0000-0002-8391-6393
Xilian WangThe First Affiliated Hospital, Department of Pain, Hengyang Medical School, University of South China, 421001, China.ORCID https://orcid.org/0000-0002-8604-8704
University of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To research the impact and mechanism of endothelin receptor A inhibitor BQ-123 combined with electroacupuncture on tibia cancer pain in rats. Methods: Sprague-Dawley (SD) rats were randomly divided into sham group (SHAM group) and bone cancer pain model group (BCP group). The behavior of SD rats was measured. The histology of the right tibia was observed by hematoxylin-eosin (HE) staining. The remaining rats were randomly divided into model, BQ-123, electroacupuncture, and BQ-123+ electroacupuncture group. Behavioral tests were performed, and mechanical pain threshold (MWT) and thermal pain threshold (TWL) were measured. The expressions of Results: In the BCP group, bone structure was severely damaged, local tissue swelling was obvious, bone trabecula was missing, and bone cortex was discontinuous. The optical density of Glial fibrillary acidic protein (GFAP) and CD11b immunoreactive signal in BCP group was significantly increased, and most of the ETAR of endothelin receptor was comapped with NeuN, and a small part of GFAP was comapped with CD11b, but no comapped with CD11b. The AS score of BQ-123+ electroacupuncture group was significantly lower than that of BQ-123 group and electroacupuncture group ( Conclusion: BQ-123 may inhibit the activation of PI3K/Akt signal path combined with electroacupuncture to alleviate the effects of tibia cancer pain in rats.

Indexed as

Cancer PainElectroacupunctureNeoplasmsAnimalsHumansPeptides, CyclicPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleyReceptor, Endothelin ATibiacyclo(Trp-Asp-Pro-Val-Leu)Peptides, CyclicPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReceptor, Endothelin A

Identifiers

PMID35620269
PMCPMC9129989
OpenAlexW4280582809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.