Evidence map›Paper›PMID 35620221›Full record

ArticleCurrent epidemiology reports2022

The importance of addressing early life environmental exposures in cancer epidemiology.

Nicole M Niehoff, Mandy Goldberg, Alexandra J White

Abstract read
In one paragraph

Article in Current epidemiology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Methodological Pitfalls Undermine Industrial Emission-related Lung Cancer Risk Assessment.American journal of respiratory and critical care medicine · 2025
    Article
  2. Article
  3. Article
  4. Lifetime Exposure to Cigarette Smoke and Risk of Ovarian Cancer by T-cell Tumor Immune Infiltration.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nicole M NiehoffEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.ORCID 0000-0002-5852-3010
Mandy GoldbergEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.ORCID 0000-0002-6794-1206
Alexandra J WhiteEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.ORCID 0000-0003-2455-2945

Funding

Environment and Cancer EpidemiologyZIAES103332 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WHITE, ALEXANDRA · 2019 to 2025
$8.9M
Intramural NIH HHS ZIA ES103332
6 · The paper itself

Abstract

Purpose of Review: Environmental exposures during early stages of life may be particularly relevant for cancer etiology because of the rapid hormonal and tissue changes that occur during puberty and, in women, through first birth. We review evidence from the past five years on environmental exposures during childhood/adolescence through first birth and the risk of breast and other cancers during adulthood. Recent Findings: The studies of breast cancer (n=14) reported associations for childhood/adolescent environmental tobacco smoke (ETS), smoking initiation, pesticides, hair dye use, and living on a road with high traffic. Smoking before first childbirth was also associated with increased breast cancer risk. We identified 12 studies on other cancers, with only 1-2 studies per cancer type, with most focused on ETS or active smoking. Summary: Despite studies suggesting an important role of exposure to environmental factors during early life and cancer risk in adulthood, few studies have been conducted. Future studies could utilize stored biologic samples from relevant periods or complete residential histories for geographically-based exposures.

Indexed as

breast cancercancerearly lifeenvironmentwindows of susceptibility

Identifiers

PMID35620221
PMCPMC9128626

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.