Evidence map›Paper›PMID 35620067›Full record

ArticleSTAR protocols2022

A modified surgical procedure using minimally invasive ileocolic vein perfusion in a mouse intrahepatic islet transplant model.

Lei Zhang, Ali Turan, Haval Shirwan, Esma S Yolcu

Open access · goldAbstract read
In one paragraph

Article in STAR protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Engineering pancreatic islets with a novel form of thrombomodulin protein to overcome early graft loss triggered by instant blood-mediated inflammatory reaction.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Lei ZhangDepartment of Child Health, University of Missouri, Columbia, MO 65211, USA.
Ali TuranDepartment of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO 65211, USA.
Haval ShirwanDepartment of Child Health, University of Missouri, Columbia, MO 65211, USA.
Esma S YolcuDepartment of Child Health, University of Missouri, Columbia, MO 65211, USA.
University of Missouri Health System · USUniversity of Missouri · US

Funding

Targeted delivery of immunomodulatory biologics for induction of immune privilege to allogeneic pancreatic islet graftsU01AI132817 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI GARCIA, ANDRES J, SHIRWAN, HAVAL · 2017 to 2021
$2.0M
A novel immunomodulatory approach to overcome innate and adaptiveimmune barriers to islet transplantationR01AI121281 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI SHIRWAN, HAVAL · 2019 to 2024
$1.9M
NIAID NIH HHS R01 AI121281NIAID NIH HHS U01 AI132817
6 · The paper itself

Abstract

Murine intrahepatic islet transplantation is a clinically relevant but technically challenging surgical procedure because of frequent lethal postoperative bleeding. Here, we describe a protocol for mouse pancreatic islet isolation, purification, and culture. Besides, we also describe a protocol for intrahepatic islet transplantation through the ileocolic vein. Intrahepatic islet transplantation through the ileocolic vein, as opposed to traditional islet perfusion via the main portal vein, has the advantage of improving recovery after surgery and may facilitate islet survival and function in preclinical settings. For complete details on the use and execution of this protocol, please refer to Shrestha et al. (2020).

Indexed as

Islets of Langerhans TransplantationTransplantsAnimalsDisease Models, AnimalMesenteric VeinsMicePerfusionPortal VeinHealth SciencesModel Organisms

Identifiers

PMID35620067
PMCPMC9127695
OpenAlexW4280614620

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.