ArticleFrontiers in nutrition2022
Association Between Dietary Inflammatory Index and S-Klotho Plasma Levels in Middle-Aged and Elderly People.
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Assessing the Association of the Dietary Inflammatory Index With Stroke Risk and All-Cause Mortality Among Hypertension Patients: A NHANES Cross-Sectional Study (2005-2018).Journal of central nervous system disease · 2026Article
- Association of sarcopenia and frailty with sleep quality trajectories in middle-aged and older Chinese adults: findings from a nationally representative cohort study.BMC public health · 2025Article
- Systemic immune-inflammation index mediates the association between abdominal obesity and serum klotho levels.Scientific reports · 2025Article
- Association between dietary inflammatory index and epilepsy: findings from NHANES.Frontiers in neurology · 2025Article
- Systemic inflammation mediates the association between the dietary index for gut microbiota and serum Klotho: evidence from NHANES 2007-2016.Frontiers in nutrition · 2025Article
- Associations of weight-adjusted-waist index and systemic immune-inflammatory index with sKlotho: evidence from the NHANES 2007-2016.Frontiers in endocrinology · 2025Article
- Article
- Exploring the association between dietary Inflammatory Index and chronic pain in US adults using NHANES 1999-2004.Scientific reports · 2024Article
- Dietary Inflammatory Index and female infertility: findings from NHANES survey.Frontiers in nutrition · 2024Article
- Association between dietary inflammatory index and chronic kidney disease in middle-aged and elderly populations.Frontiers in nutrition · 2024Article
- Article
- Inverted U-shaped relationship between serum vitamin B12 and α-Klotho levels in US adults: a cross-sectional study.Frontiers in nutrition · 2024Article
- Article
- Dietary inflammatory potential and biological aging among US adults: a population-based study.Aging clinical and experimental research · 2023Article
- Aging and antioxidants: the impact of dietary carotenoid intakes on soluble klotho levels in aged adults.Frontiers in endocrinology · 2023Article
- The association between dietary inflammatory index with endometriosis: NHANES 2001-2006.PloS one · 2023Article
- A cross-sectional analysis of association between visceral adiposity index and serum anti-aging protein Klotho in adults.Frontiers in endocrinology · 2023Article
- Associations between the Healthy Eating Index-2015 and S-Klotho plasma levels: A cross-sectional analysis in middle-to-older aged adults.Frontiers in nutrition · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Soluble Klotho (S-Klotho) is a protein that has anti-aging properties. Dietary inflammation index (DII) is closely related to various age-related diseases. However, whether DII is related to S-Klotho plasma levels is still controversial. It was the goal of this study to examine the link between DII and S-Klotho in middle-aged and elderly people. Methods: Between 2007 and 2016, five NHANES cycles were conducted, with 12,315 middle-aged and elderly (aged 40-79) participants having S-Klotho tests and submitting dietary recall data. The inflammatory potential of a diet was determined using the DII. To determine the plasma levels of S-Klotho, we employed a solid-phase sandwich enzyme-linked immunosorbent assay (ELISA). Results: There was a negative correlation between DII and S-Klotho plasma levels. In the threshold effect analysis model, the breakpoint was DII=1.3, and the negative correlation was more obvious when DII < 1.3 (β = -10.6, Conclusion: In middle-aged and older individuals, there is a negative connection between the pro-inflammatory dietary pattern as evaluated by DII and the plasma level of S-Klotho. Given the rationale for the findings and the study's limitations, the fundamental mechanisms generating inflammation warrant additional exploration.
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