Evidence map›Paper›PMID 35619736›Full record

ArticleInfection and drug resistance2022

Prevalence and Predictors of Persistent Symptoms After Clearance of SARS-CoV-2 Infection: A Multicenter Study from Egypt.

Marwa Khalaf, Mohamed Alboraie, Muhammad Abdel-Gawad, Mohamed Abdelmalek, Ahmed Abu-Elfatth, Walaa Abdelhamed, Mariam Zaghloul, Rabab ElDeeb, Doaa Abdeltwab, Mohamed Abdelghani and 11 more

Abstract read
In one paragraph

Article in Infection and drug resistance, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Marwa KhalafAssiut Liver Center, Ministry of Health, Assiut, 71515, Egypt.
Mohamed AlboraieDepartment of Internal Medicine, Al-Azhar University, Cairo, Egypt.ORCID 0000-0002-8490-9822
Muhammad Abdel-GawadHepatology, Gastroenterology and Infectious Diseases Department, Al-Azhar University, Assiut, Egypt.ORCID 0000-0002-0204-4715
Mohamed AbdelmalekTropical Medicine and Gastroenterology Department, Assiut University, Assiut, Egypt.
Ahmed Abu-ElfatthTropical Medicine and Gastroenterology Department, Assiut University, Assiut, Egypt.
Walaa AbdelhamedTropical Medicine and Gastroenterology Department, Sohag University Hospital, Sohag, Egypt.
Mariam ZaghloulHepatology, Gastroenterology and Infectious Diseases Department, Kafr El-Sheikh University, Kafr El-Sheikh, Egypt.ORCID 0000-0002-4244-5396
Rabab ElDeebTropical Medicine Department, Alexandria University, Alexandria, Egypt.ORCID 0000-0003-0396-1870
Doaa AbdeltwabTropical Medicine and Gastroenterology Department, Assiut University, Assiut, Egypt.
Mohamed AbdelghaniTropical Medicine and Gastroenterology Department, Assiut University, Assiut, Egypt.
Fathiya El-RaeyHepatogastroenterology and Infectious Diseases Department, Al-Azhar University, Damietta, Egypt.
Hani AboalamAssiut Liver Center, Ministry of Health, Assiut, 71515, Egypt.
Azza BadryEpidemiologist, Infectious Disease Control Department Preventive Medicine Assiut Health Affairs Directorate, Assiut, Egypt.
Mina TharwatTropical Medicine and Gastroenterology Department, Aswan University, Aswan, Egypt.
Shima AfifyGastroenterology Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt.
Doaa ElwazzanTropical Medicine Department, Alexandria University, Alexandria, Egypt.
Ahmed Shawkat AbdelmohsenTropical Medicine and Gastroenterology Department, Assiut University, Assiut, Egypt.ORCID 0000-0002-7429-4529
Hayam FathyInternal Medicine, Hepatogastroenterology Unit, Assiut University, Assiut, Egypt.ORCID 0000-0001-5289-303X
Shaker Wagih ShaltoutTropical Medicine Department, Port Said University, Port Said, Egypt.ORCID 0000-0002-4304-3276
Helal F HettaDepartment of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.ORCID 0000-0001-8541-7304
Shamardan E BazeedTropical Medicine and Gastroenterology Department, South Valley University, Qena, Egypt.ORCID 0000-0001-7653-0006

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aim: Little is known about the persistence of symptoms after clearance of SARS-CoV-2 infection. Our study aimed to assess persistent symptoms in COVID-19 patients after clearance of SARS-CoV-2 infection. Methodology: A multi-center survey was conducted on first wave COVID-19 patients with confirmed SARS-CoV-2 infection. Sociodemographic and clinical characteristics, including presenting symptoms and persistent symptoms after viral clearance and possible factors contributing to persistence of such symptoms, were collected using an online multicomponent questionnaire. Descriptive and inferential statistical analysis was performed to detect the most persisting symptoms and factors contributing to their persistence. Results: Overall, 538 patients were enrolled. Mean age was 41.17 (±SD 14.84), 54.1% were males, and 18.6% were smokers. Hypertension and diabetes were the most reported co-morbidities. Mild symptoms were reported in 61.3% of patients, 51.3% were admitted to hospital and 6.5% were admitted to the intensive care unit. Our study identified 49 types of persisting symptoms. Fatigue (59.1%), sense of fever (46.5%), anorexia (24.3%) and diarrhea (24.3%) were the most commonly reported persisting symptoms followed by loss of taste and smell (22.3%), headache (21.4%), cough (20.8) and dyspnea (21%). The use of hydroxychloroquine, azithromycin and multivitamins were significantly associated with persistence of symptoms (OR = 8.03, 8.89 and 10.12, respectively). Conclusion: Our study revealed that in COVID-19 recovered patients, many patients reported persistence of at least one symptom, particularly fatigue and sense of fever. Follow-up of patients after discharge from hospital is recommended until complete resolution of symptoms.

Indexed as

coronavirusCOVID-19dyspneafatigueSARS-CoV-2

Identifiers

PMID35619736
PMCPMC9128749

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.