Evidence map›Paper›PMID 35619712›Full record

ArticleFrontiers in immunology2022

Beyond Maternal Tolerance: Education of Uterine Natural Killer Cells by Maternal MHC Drives Fetal Growth.

Delphine M Depierreux, Jens Kieckbusch, Norman Shreeve, Delia A Hawkes, Bryan Marsh, Robert Blelloch, Andrew Sharkey, Francesco Colucci

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Innate Lymphoid Cells in Reproductive Health and Disease.European journal of immunology · 2025
    Review
  5. Natural Killer Cell Education in Women With Recurrent Pregnancy Loss.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Delphine M DepierreuxDepartment of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, United Kingdom.
Jens KieckbuschDepartment of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, United Kingdom.
Norman ShreeveDepartment of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, United Kingdom.
Delia A HawkesDepartment of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, United Kingdom.
Bryan MarshDepartment of Urology, University of California, San Francisco, San Francisco, CA, United States.
Robert BlellochDepartment of Urology, University of California, San Francisco, San Francisco, CA, United States.
Andrew SharkeyCentre for Trophoblast Research, University of Cambridge, Cambridge, United Kingdom.
Francesco ColucciDepartment of Obstetrics and Gynaecology, University of Cambridge School of Clinical Medicine, NIHR Cambridge Biomedical Research Centre, Addenbrooke's Hospital, Cambridge, United Kingdom.
University of Cambridge · GBNIHR Cambridge Biomedical Research CentreUniversity of California, San Francisco · US

Funding

PREDOCTORAL TRAINING IN DEVELOPMENTAL BIOLOGYT32HD007470 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Todd Nystul · 1994 to 2026
$7.7M
Department of HealthMedical Research Council MR/P001092/1NICHD NIH HHS T32 HD007470Wellcome Trust 094073/Z/10/ZWellcome Trust 200841/Z/16/Z
6 · The paper itself

Abstract

Reproductive immunology has moved on from the classical Medawar question of 60 years ago "

Indexed as

Killer Cells, NaturalUterusAnimalsFemaleFetal DevelopmentHumansImmune ToleranceMicePregnancyReceptors, Natural Killer CellReceptors, Natural Killer Celleducationfetal growthpregnancyreproductive immunologyuterine natural killerβ2m

Identifiers

PMID35619712
PMCPMC9127083
OpenAlexW4229456741

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.