ArticleAlzheimer's research & therapy2022
Association between Life's Simple 7 and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: the CABLE study.
Article in Alzheimer's research & therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 19 citations in OpenAlex.
- Impact of mid-life cardiovascular health on cognitive change in a bi-ethnic cohort.medRxiv : the preprint server for health sciences · 2025Article
- Associations between platelet indices and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: the CABLE study.Alzheimer's research & therapy · 2025Article
- ANU-ADRI scores, tau pathology, and cognition in non-demented adults: the CABLE study.Alzheimer's research & therapy · 2024Article
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Authors and funding
7 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionThis study sought to explore the association between Life's Simple 7 (LS7) and cerebrospinal fluid (CSF) Alzheimer's disease (AD) pathological biomarkers in the cognitively normal northern Chinese population.
methodsFrom the Chinese Alzheimer's Biomarker and LifestylE (CABLE) study, 1106 cognitively normal participants were enrolled. The mean age was 62.34 years, and 39.6% were female. LS7 scores were summed with each metric assigned 0, 1, or 2 scores. The multiple linear regression models were used to investigate the association between LS7 scores and CSF AD biomarkers.
resultsWe found that LS7 scores were significantly associated with CSF AD pathologies, including Aβ42/40 (β = 0.034, P = .041), p-tau181 (β = - 0.043, P = .006), and t-tau (β = - 0.044, P = .003). In subscales, the biological metrics (blood pressure, cholesterol, glucose) were significantly related to CSF tau-related biomarkers. These associations were observed in the APOE ε4 allele non-carriers, yet not in carriers. The relationship of behavior metrics was found in the middle age and males.
conclusionImproving LS7 scores might do a favor to alleviate the pathology of AD in the preclinical stage, especially among the APOE ε4 allele non-carriers.
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