ArticleBMC geriatrics2022
Type 2 diabetes mellitus and cognitive decline in older adults in Germany - results from a population-based cohort.
Article in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Cognitive Impairment in People with Type 2 Diabetes Mellitus: Associations with Inflammatory and Vascular Markers.Annals of neurosciences · 2026Article
- The Variant T Allele ofBiomolecules · 2026Article
- Linking inflammation, metabolic dysfunction, and neurodegeneration: a comprehensive review of TLR2 pathways in type 2 diabetes.Frontiers in clinical diabetes and healthcare · 2026Review
- GLP-1 Receptor Agonist Therapy in Older Adults with Diabetes: A Qualitative Analysis of Phase 4 ClinicalTrials.gov Studies.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Associations of Glycemic Control with Cognitive Flexibility and Mental Health-Related Quality of Life in Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Internal factors related to self-management among type 2 diabetes patients during the COVID-19 pandemic as humanitarian emergencies: a scoping review protocol.Systematic reviews · 2025Article
- Statin therapy on dementia in elderly type 2 diabetes patients with delirium.Diabetology & metabolic syndrome · 2025Article
- Self-management of patients with type 2 diabetes in Chaoyang District, Beijing, and challenges in utilizing family and community resources: a mixed-methods study.BMC primary care · 2025Article
- Prevalence and Predictors of Cognitive Decline Among Diabetes Mellitus Patients Attending Jinja Regional Referral Hospital: A Cross-Sectional Study in Eastern Uganda.Health science reports · 2025Article
- Impaired neurovascular coupling in metabolic syndrome: an fNIRS study.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Factors associated with cognitive function outcomes among older adults in Kuwait: A cross-sectional study.BMC geriatrics · 2025Article
- The influencing factors of cognitive impairment in elderly individuals in Chengdu city: a cross-sectional study based on AD8.BMC geriatrics · 2025Article
- Observational
- Chromogranin a gene variants influence survival at old age through pleiotropic effects on multiple age-related traits.Frontiers in aging · 2025Article
- Qigong in the care of breast cancer survivors with diabetes.Asia-Pacific journal of oncology nursing · 2024Article
- The importance of rapid assessment tools in evaluating mental health in emergency departments among patients with chronic diseases.Frontiers in public health · 2024Observational
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundA large body of evidence supports a link between type 2 diabetes mellitus (T2DM) and cognitive function, including dementia. However, longitudinal studies on the association between T2DM and decline of cognitive function are scarce and reported mixed results, and we hence set out to investigate the cross-sectional and longitudinal association between T2DM and global as well as domain-specific cognitive performance.
methodsWe used multivariable regression models to assess associations of T2DM with cognitive performance and cognitive decline in a subsample of a population-based prospective cohort study (ESTHER). This subsample (n = 732) was aged 70 years and older and had participated in telephone-based cognitive function assessment (COGTEL) measuring global and domain-specific cognitive performance during the 5- and 8-year follow-up.
resultsTotal COGTEL scores of patients with prevalent T2DM were 27.4 ± 8.3 and 29.4 ± 8.7 at the 5- and 8-year measurements, respectively, and were roughly two points lower than those of T2DM-free participants after adjustment for age and sex. In cross-sectional models, after adjustment for several potential confounders, performance in verbal short-term and long-term memory tasks was statistically significantly lower in participants with T2DM, but the association was attenuated after further adjustment for vascular risk factors. The difference in total COGTEL scores reflecting global cognitive function by T2DM status after full adjustment for confounders and vascular risk factors was equivalent to a decrement in global cognitive function associated with a four-year age difference. In longitudinal models, a statistically significantly stronger cognitive decline in patients with T2DM was observed for working memory.
conclusionsIn this sample of older individuals, T2DM was associated with worse performance and stronger decline in a cognitive function test. Memory-related domains were found to be particularly sensitive to T2DM. Further large-scale prospective studies are needed to clarify potential T2DM-related predictors of cognitive decline and possible consequences on the abilities to perform patient self-management tasks in diabetes care.
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