Evidence map›Paper›PMID 35618964›Full record

ArticleClinical rheumatology2022

Absence of association between nailfold capillary findings and mild cognitive dysfunction in systemic lupus erythematosus.

Pamela Munguía-Realpozo, Mario García-Carrasco, Claudia Mendoza-Pinto, María de Lourdes Galaviz-Silva, Ivet Etchegaray-Morales, Socorro Méndez-Martínez, Álvaro José Montiel-Jarquín, Luis G Vázquez de Lara, Luis H Silveira

Abstract read
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In one paragraph

Article in Clinical rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Pamela Munguía-RealpozoDepartment of Rheumatology, Medicine School, Meritorious Autonomous University of Puebla, Puebla, Mexico.ORCID http://orcid.org/0000-0002-6967-7939
Mario García-CarrascoDepartment of Rheumatology, Medicine School, Meritorious Autonomous University of Puebla, Puebla, Mexico.ORCID http://orcid.org/0000-0003-1696-9871
Claudia Mendoza-PintoDepartment of Rheumatology, Medicine School, Meritorious Autonomous University of Puebla, Puebla, Mexico. cmp_26@yahoo.com.mx.ORCID http://orcid.org/0000-0002-5101-7705
María de Lourdes Galaviz-SilvaDepartment of Rheumatology, Medicine School, Meritorious Autonomous University of Puebla, Puebla, Mexico.ORCID http://orcid.org/0000-0003-4967-7963
Ivet Etchegaray-MoralesDepartment of Rheumatology, Medicine School, Meritorious Autonomous University of Puebla, Puebla, Mexico.ORCID http://orcid.org/0000-0002-5857-4299
Socorro Méndez-MartínezCoordination of Health Research, Mexican Social Security Institute, Puebla, Mexico.ORCID http://orcid.org/0000-0001-7463-0580
Álvaro José Montiel-JarquínDirection of Education and Health Research, Specialties Hospital UMAE, Mexican Social Security Institute, Puebla, Mexico.ORCID http://orcid.org/0000-0003-0531-9611
Luis G Vázquez de LaraLaboratory of Experimental Medicine, Medicine School, Meritorious Autonomous University of Puebla, Puebla, Mexico.ORCID http://orcid.org/0000-0002-8219-2135
Luis H SilveiraDepartment of Rheumatology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Benemérita Universidad Autónoma de Puebla · MXMexican Social Security Institute · MXInstituto Nacional de Cardiología · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe role of vascular damage in cognitive dysfunction (CD) in SLE is not entirely understood. Nailfold capillaroscopy (NFC) is a noninvasive method that may aid the description of further vascular contributions to CD in SLE. Therefore, the aim of our study was to examine and compare finger nailfold capillary morphology in subjects with SLE with and without CD.

methodsWe conducted a cross-sectional study in patients with SLE. Demographic, clinical, and laboratory characteristics were collected. We evaluated nailfold capillary findings including avascular zones, hemorrhage, dilated and tortuous capillaries, disarrangement, crossing, subpapillary venular plexus, branched loops, and shortened loops by NFC. The Montreal Cognitive Assessment (MoCA) scale was used to screen cognitive function. CD was defined as a score < 26/30.

resultsSixty-five females (97.0%) and 2 males (3%) with SLE were analyzed. Means of age and disease duration were 44.3 ± 12.0 years and 15.5 ± 7.6 years, respectively. Thirty-five (54.7%) patients had CD. The rate of patients with ≥ 1 NFC abnormality was 50% in both patients with and without CD (P = 0.14). Eight (22.8%) patients with CD compared to 1 without (3.5%) displayed dilated capillaries (P = 0.036). Other NFC abnormalities differed between patients with and without CD, but the possible relationships between dilated capillaries and CD disappeared after adjusting by age, diabetes, and hypertension.

conclusionsNFC findings were not associated with mild CD in patients with SLE. Our exploratory data do not support systemic microvasculopathy measured by NFC related to CD in patients with SLE.

Indexed as

Cognitive DysfunctionLupus Erythematosus, SystemicCapillariesCross-Sectional StudiesFemaleHumansMaleMicroscopic AngioscopyNailsCognitive dysfunctionNailfold capillaroscopySystemic lupus erythematosus

Identifiers

PMID35618964
OpenAlexW4281721777

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.