Evidence map›Paper›PMID 35618961›Full record

Trial reportClinical oral investigations2022

Efficacy of concentrated growth factor versus collagen membrane in reconstructive surgical therapy of peri-implantitis: 3-year results of a randomized clinical trial.

Sila Cagri Isler, Fatma Soysal, Tugce Ceyhanlı, Batuhan Bakırarar, Berrin Unsal

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04769609 (Reconstructive Surgical Therapy of Peri-implantitis), which is not on this map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04769609 completednot on this map

Reconstructive Surgical Therapy of Peri-implantitis: 3-year Results of a Randomized Clinical Trial

TypeobservationalSponsorGazi UniversityRan2020 to 2021Enrolled52ConditionsPeri-ImplantitisArmsbioresorbable membrane
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Sila Cagri IslerDepartment of Periodontology, Faculty of Dentistry, Gazi University, Ankara, Turkey. silaisler@gazi.edu.tr.ORCID http://orcid.org/0000-0001-5419-9658
Fatma SoysalDepartment of Periodontology, Faculty of Dentistry, Ankara Medipol University, Ankara, Turkey.
Tugce CeyhanlıDepartment of Periodontology, Faculty of Dentistry, Yeditepe University, Istanbul, Turkey.
Batuhan BakırararDepartment of Biostatistics, Faculty of Medicine, Ankara University, Ankara, Turkey.
Berrin UnsalDepartment of Periodontology, Faculty of Dentistry, Gazi University, Ankara, Turkey.
Ankara University · TRGazi University · TRIstanbul Medipol University · TRUniversity of Bern · CHYeditepe University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo compare the 3-year clinical and radiographic outcomes of two different reconstructive surgical management of peri-implantitis using a bone substitute in combination with either concentrated growth factor (CGF) or collagen membrane (CM). MATERIAL AND

methodsFifty-one patients who had at least one implant presenting peri-implantitis with an intrabony defect were filled with a xenogenic bone grafting material and covered either CGF or CM. Clinical and radiographic assessments were carried out at baseline and postoperative years 1 and 3. Three different composite outcomes were defined to evaluate treatment success at a 3-year follow-up. The effects of possible prognostic indicators on treatment success were identified by using multilevel regression analysis.

resultsThe changes in probing depth (PD) and radiographic vertical defect depth (VDD) between baseline and year 1 and baseline and year 3 presented significantly greater decreases for the CM group in comparison with the CGF group (p < 0.05). No significant differences between the two treatment modalities were demonstrated regarding treatment success outcomes. History of periodontitis, VDD at baseline, and the number of intrabony defect walls revealed significant impacts on treatment success (p = 0.033; OR = 3.50, p = 0.039; OR = 0.975, and p = 0.024; OR = 7.0 and p = 0.019;OR = 6.0, respectively).

conclusionsCM in combination with a bone substitute seems to have slightly better outcomes compared to the CGF membranes in reconstructive surgical therapy of peri-implantitis. The history of periodontitis, baseline VDD, and peri-implant bone defect configuration could be possible predictors influencing treatment success.

trial registrationClinicalTrials.gov NCT04769609. CLINICAL RELEVANCE: For the reconstruction of peri-implant bone defects, using a bone substitute in combination with a collagen membrane may show more favorable outcomes.

Indexed as

Bone SubstitutesDental ImplantsPeri-ImplantitisCollagenHumansIntercellular Signaling Peptides and ProteinsTreatment OutcomeBone SubstitutesCollagenDental ImplantsIntercellular Signaling Peptides and ProteinsBlood plateletsMaintenanceMembranesPeri-implantitisReconstructive surgical proceduresSubmerged healing

Identifiers

PMID35618961
PMCPMC9381616
OpenAlexW4281556484

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.