ArticleNature metabolism2022
PARK7/DJ-1 promotes pyruvate dehydrogenase activity and maintains T
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Article in Nature metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
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34 citing papers in PubMed, 47 citations in OpenAlex.
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- Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer.International journal of cancer · 2026Review
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- A modular, mechanism-informed biomarker panel for asthenozoospermia based on integrative sperm proteomics.Frontiers in endocrinology · 2026Article
- Unveiling the metal-driven death: ferroptosis and cuproptosis in leukemia.European journal of medical research · 2025Review
- Single-cell transcriptomics reveals dynamic reprogramming of testicular immunity inZoological research · 2025Article
- Cuproptosis Signature Would Reveal the Acute-Remitting Pattern in Patients with Neuromyelitis Optica Spectrum Disorder.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Regulatory T cells in homeostasis and disease: molecular mechanisms and therapeutic potential.Signal transduction and targeted therapy · 2025Review
- Metabolic Dysregulation in Parkinson's Disease: Non-Oxidative Phosphorylation and Its Role in Brain Energy Metabolism.Aging and disease · 2025Review
- Targeting T-cell Aging to Remodel the Aging Immune System and Revitalize Geriatric Immunotherapy.Aging and disease · 2025Review
- Hyperglycemia-induced oxidative stress exacerbates mitochondrial apoptosis damage to cochlear stria vascularis pericytes via the ROS-mediated Bcl-2/CytC/AIF pathway.Redox report : communications in free radical research · 2024Article
- Deep Learning and Single-Cell Sequencing Analyses Unveiling Key Molecular Features in the Progression of Carotid Atherosclerotic Plaque.Journal of cellular and molecular medicine · 2024Article
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- Cellular senescence and metabolic reprogramming: Unraveling the intricate crosstalk in the immunosuppressive tumor microenvironment.Cancer communications (London, England) · 2024Review
- Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system.Bone research · 2024Review
- Inferring upstream regulatory genes of FOXP3 in human regulatory T cells from time-series transcriptomic data.NPJ systems biology and applications · 2024Article
- Bioinformatics reveals diagnostic potential of cuproptosis-related genes in the pathogenesis of sepsis.Heliyon · 2024Article
- The immunometabolic ecosystem in cancer.Nature immunology · 2023Review
Corrections and comments
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Authors and funding
30 authors at 8 institutions in 4 countries.
Egle Danileviciute *Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.
Ni Zeng *Department of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.ORCID http://orcid.org/0000-0003-2756-6074
Christophe M CapelleDepartment of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.ORCID http://orcid.org/0000-0002-9110-9583
Nicole PacziaLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.
Mark A GillespieInstitute for Systems Biology, Seattle, WA, USA.
Henry KurniawanDepartment of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.
Mohaned BenzartiFaculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Myriam P MerzDepartment of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.
Djalil CoowarLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.
Sabrina FritahNORLUX Neuro-Oncology Laboratory, Department of Cancer Research, LIH, Luxembourg, Luxembourg.ORCID http://orcid.org/0000-0002-7613-1424
Daniela Maria Vogt WeisenhornHelmholtz Zentrum München-German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany.ORCID http://orcid.org/0000-0002-4566-6506
Gemma Gomez GiroLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.
Melanie GrusdatDepartment of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.
Alexandre BaronDepartment of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.
Coralie GuerinDepartment of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.ORCID http://orcid.org/0000-0002-1840-4017
Davide G FranchinaDepartment of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.ORCID http://orcid.org/0000-0001-9824-5302
Cathy LéonardDepartment of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.ORCID http://orcid.org/0000-0002-2655-2343
Olivia DominguesDepartment of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.
Sylvie DelhalleDepartment of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.ORCID http://orcid.org/0000-0002-5573-754X
Wolfgang WurstHelmholtz Zentrum München-German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany.
Jonathan D TurnerDepartment of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.ORCID http://orcid.org/0000-0002-2760-1071
Jens Christian SchwambornLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.ORCID http://orcid.org/0000-0003-4496-0559
Johannes MeiserCancer Metabolism Group, Department of Cancer Research, LIH, Luxembourg, Luxembourg.ORCID http://orcid.org/0000-0002-9093-6210
Rejko KrügerLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.
Jeff RanishInstitute for Systems Biology, Seattle, WA, USA.
Dirk BrennerDepartment of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.ORCID http://orcid.org/0000-0001-8979-1045
Carole L LinsterLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.
Rudi BallingLuxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg.
Markus OllertDepartment of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg.
Feng Q HefengDepartment of Infection and Immunity, Luxembourg Institute of Health (LIH), Esch-sur-Alzette, Luxembourg. feng.he@lih.lu.ORCID http://orcid.org/0000-0003-2657-7361
University of Luxembourg · LULuxembourg Institute of Health · LUInstitute for Systems Biology · USUniversity of Southern Denmark · DKCentre Hospitalier de Luxembourg · LUGerman Center for Neurodegenerative Diseases · DEHelmholtz Zentrum München · DEUniversity of Bonn · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyruvate dehydrogenase (PDH) is the gatekeeper enzyme of the tricarboxylic acid (TCA) cycle. Here we show that the deglycase DJ-1 (encoded by PARK7, a key familial Parkinson's disease gene) is a pacemaker regulating PDH activity in CD4
Indexed as
OxidoreductasesParkinson DiseaseProtein Deglycase DJ-1PyruvatesT-Lymphocytes, RegulatoryAgingAnimalsHomeostasisMiceOxidoreductasesPARK7 protein, mouseProtein Deglycase DJ-1Pyruvates
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