ArticleEuropean journal of nutrition2022
Amino acid-balanced diets improved DSS-induced colitis by alleviating inflammation and regulating gut microbiota.
Article in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- A Multi-Target Approach to Colitis: Ergothioneine Promotes Recovery by Restoring the Intestinal Barrier, Reducing Inflammation, and Remodeling the Microbiota.Food science & nutrition · 2026Article
- Low-Molecular-Weight Fucoidan fromFoods (Basel, Switzerland) · 2026Article
- Potential Benefits of Gut Microbiota Modulation in Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2026Article
- Inhibitory effects and amino acid metabolism regulations of active polyphenol from foxtail millet bran on chronic colitis in mice.Frontiers in nutrition · 2025Article
- Modulation of Inflammation Levels and the Gut Microbiota in Mice with DSS-Induced Colitis by a Balanced Vegetable Protein Diet.Plant foods for human nutrition (Dordrecht, Netherlands) · 2024Article
- Milk andAmerican journal of physiology. Gastrointestinal and liver physiology · 2024Article
- Porcine Intestinal Mucosal Peptides Target Macrophage-Modulated Inflammation and Alleviate Intestinal Homeostasis in Dextrose Sodium Sulfate-Induced Colitis in Mice.Foods (Basel, Switzerland) · 2024Article
- The Effects of Synbiotics on Dextran-Sodium-Sulfate-Induced Acute Colitis: The Impact of Chitosan Oligosaccharides on Endogenous/ExogenousFoods (Basel, Switzerland) · 2023Article
- The role ofFrontiers in immunology · 2022Review
- Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
purposeInflammatory bowel disease (IBD) is a multifactorial chronic disease of the gastrointestinal tract. Dietary intervention in the treatment of IBD has gradually attracted more attention. In this study, amino acid-balanced diets (AABD) based on grains were developed and their influences on the regulation of IBD were investigated.
methodsDextran sodium sulfate (DSS)-induced acute colitis mice model was employed to evaluate the effects of AABD. Pathological symptoms, intestinal inflammation, gut barrier proteins and gut microbiota were determined after AABD intake.
resultsIt was shown that AABD alleviated the symptoms of colitis by reducing the histological scores of mice colon, suppressing the expression of pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α) and upregulating the expression of tight junction proteins. Analysis of gut microbiota revealed that AABD altered the structure of gut microbiota by decreasing the abundance and richness of harmful bacteria induced by DSS (Escherichia-Shigella, Parasutterella, etc.) and increasing that of beneficial bacteria (Akkermansia, etc.). Correlation analysis indicated that the alterations of pro-inflammatory factors were related with the change of microbiota, suggesting that the inhibitory effects of AABD on inflammation might be due to its regulation gut microbiota.
conclusionThe AABD could efficiently mitigate colitis, and this study indicated that AABD could be applied as a promising dietary regulation strategy of IBD.
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