Evidence map›Paper›PMID 35618869›Full record

ArticleCardiovascular engineering and technology2023

Quantifying Cardiothoracic Variation with Posture and Respiration to Inform Cardiac Device Design.

Geeth A Kondaveeti, Varun A Bhatia, Ryan P Lahm, Megan L Harris, James P Gaewsky, F Scott Gayzik, John F Greenhalgh, Craig A Hamilton, R Brandon Stacey, Ashley A Weaver

Open access · greenAbstract read
In one paragraph

Article in Cardiovascular engineering and technology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Geeth A KondaveetiDepartment of Biomedical Engineering, Wake Forest School of Medicine, 575 N. Patterson Ave. Suite 530, Winston-Salem, NC, 27101, USA.
Varun A BhatiaCardiac Rhythm Management, Medtronic Inc., 8200 Coral Sea Street NE, Mounds View, MN, 55112, USA.
Ryan P LahmCardiac Rhythm Management, Medtronic Inc., 8200 Coral Sea Street NE, Mounds View, MN, 55112, USA.
Megan L HarrisCardiac Rhythm Management, Medtronic Inc., 8200 Coral Sea Street NE, Mounds View, MN, 55112, USA.
James P GaewskyDepartment of Biomedical Engineering, Wake Forest School of Medicine, 575 N. Patterson Ave. Suite 530, Winston-Salem, NC, 27101, USA.
F Scott GayzikDepartment of Biomedical Engineering, Wake Forest School of Medicine, 575 N. Patterson Ave. Suite 530, Winston-Salem, NC, 27101, USA.
John F GreenhalghFONAR Corporation, 110 Marcus Drive, Melville, NY, 11747, USA.
Craig A HamiltonDepartment of Biomedical Engineering, Wake Forest School of Medicine, 575 N. Patterson Ave. Suite 530, Winston-Salem, NC, 27101, USA.
R Brandon StaceyDepartment of Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Ashley A WeaverDepartment of Biomedical Engineering, Wake Forest School of Medicine, 575 N. Patterson Ave. Suite 530, Winston-Salem, NC, 27101, USA. asweaver@wakehealth.edu.ORCID 0000-0002-4383-0106
Wake Forest University · USMedtronic (United States) · US

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
Effect of protein supplementation during weight loss on older adult bone healthK25AG058804 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WEAVER, ASHLEY · 2019 to 2023
$672k
NIA NIH HHS K25 AG058804NIA NIH HHS P30 AG021332
6 · The paper itself

Abstract

purposeWith extravascular implantable cardioverter defibrillator leads placed beneath the sternum, it is important to quantify heart motion relative to the rib cage with postural changes and respiration.

methodsMRI scans from five males and five females were collected in upright and supine postures at end inspiration [n = 10 each]. Left and right decubitus [n = 8 each] and prone [n = 5] MRIs at end inspiration and supine MRIs at end expiration [n = 5] were collected on a subset. Four cardiothoracic measurements, six cardiac measurements, and six cardiac landmarks were collected to measure changes across different postures and stages of respiration.

resultsThe relative location of the LV apex to the nearest intercostal space was significantly different between the supine and decubitus postures (average ± SD difference: - 15.7 ± 11.4 mm; p < 0.05). The heart centroid to xipho-sternal junction distance was 9.7 ± 7.9 mm greater in the supine posture when compared to the upright posture (p < 0.05). Cardiac landmark motion in the lateral direction was largest due to postural movement (range 23-50 mm) from the left decubitus to the right decubitus posture, and less influenced by respiration (5-17 mm). Caudal-cranial displacement was generally larger due to upright posture (13-23 mm caudal) and inspiration (7-20 mm cranial).

conclusionsThis study demonstrates that the location of the heart with respect to the rib cage varies with posture and respiration. The gravitational effects of postural shifts on the heart position are roughly 2-3 times larger than the effects of normal respiration.

Indexed as

Defibrillators, ImplantableFemaleHeartHumansMalePostureRespirationExtravascular implantable cardioverter defibrillator (EV ICD)Landmark motionNonischemic cardiomyopathySudden cardiac death

Identifiers

PMID35618869
PMCPMC9699900
OpenAlexW4281555966

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.