Evidence map›Paper›PMID 35618855›Full record

Trial reportWorld journal of urology2022

Intravesical aminophylline instillation as an alternative for balloon dilatation prior to semi-rigid ureteroscopic management of distal ureteral stones.

M Shabayek, T Osman, M Wahb, M Elmoazen, D Osman, A Saafan

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in World journal of urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06830577 (Efficacy of Intra-ureteric Aminophylline Instillation on Flexible Ureteroscopy Procedure), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06830577 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Intra-ureteric Aminophylline Instillation on Flexible Ureteroscopy Procedure: A Randomized Controlled Study

TypeinterventionalSponsorAin Shams UniversityRan2025 to 2026Enrolled129ConditionsStones, Kidney, Ureteric InjuryArmsUsage of Aminophylline prior to ureteric dilatation in Flexible uretroscopy, Sequential teflon dilator usage prior to ureteric access sheath placement in flexible uretroscopy, Aminophylline instillation and Ureteral dilators together
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

M ShabayekUrology department, Ain Shams University Hospitals, Abassia, 11361, Cairo, Egypt. mohamedshabayek@med.asu.edu.eg.ORCID http://orcid.org/0000-0001-7324-0732
T OsmanUrology department, Ain Shams University Hospitals, Abassia, 11361, Cairo, Egypt.
M WahbUrology department, Ain Shams University Hospitals, Abassia, 11361, Cairo, Egypt.
M ElmoazenUrology department, Ain Shams University Hospitals, Abassia, 11361, Cairo, Egypt.
D OsmanUrology department, Ain Shams University Hospitals, Abassia, 11361, Cairo, Egypt.
A SaafanUrology department, Ain Shams University Hospitals, Abassia, 11361, Cairo, Egypt.
Ain Shams University Hospital · EGAin Shams University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn a randomized controlled trial, we evaluated the effect of intravesical aminophylline instillation (IVAI) on intraureteral pressure of lower ureter and its use as an alternative to balloon dilatation after failure of advancing semi-rigid ureteroscope through the ureteric orifice without endodilatation.

methodsOur study included 83 patients with juxta-vesical distal ureteral calculi requiring endodilatation after unsuccessfully introducing the semi-rigid ureteroscope through the ureteric orifice. Patients were randomized into two groups: group A (study group) included 41 patients, where IVAI was used to dilate the ureter and facilitate ureteroscopy (the intraureteral pressure was measured using a pressure transducer connected to an invasive pressure monitor before and 5 min after IVAI), whereas group B (control group) included 42 patients, where balloon dilatation was used prior to ureteroscopy. Perioperative surgical outcomes of ureteroscopy were evaluated in both groups.

resultsA statistically significant decrease in mean intraureteral pressure of intravesical ureter was found after IVAI from 12.34 mmHg ± 1.94 before injection to 8.46 mmHg ± 1.94 after injection (P < 0.001). Ureteral injuries, postoperative pain and hematuria were statistically significantly less among the study group compared to the control group (P < 0.05). We did not find statistically significant differences in operative time, need for DJ ureteral stenting or stone-free rate between both groups and no perioperative side effects were associated with IVAI.

conclusionIn ureteroscopic management of distal ureteral stones, intravesical aminophylline instillation is safe, inexpensive and effective in reducing intraureteral pressure and achieves comparable outcomes to balloon dilatation with less ureteral injuries, postoperative pain and hematuria.

Indexed as

LithotripsyUreteral CalculiAminophyllineDilatationHematuriaHumansPostoperative PainTreatment OutcomeUreteroscopesUreteroscopyAminophyllineAminophyllineBalloon dilatationDistal ureteral stonesIntraureteral pressureUreteral stonesUreteroscopy

Identifiers

PMID35618855
PMCPMC9237005
OpenAlexW4281572243

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.