Evidence map›Paper›PMID 35618750›Full record

ArticleCommunications biology2022

The Pel polysaccharide is predominantly composed of a dimeric repeat of α-1,4 linked galactosamine and N-acetylgalactosamine.

François Le Mauff, Erum Razvi, Courtney Reichhardt, Piyanka Sivarajah, Matthew R Parsek, P Lynne Howell, Donald C Sheppard

Erratum issuedAbstract read
In one paragraph

Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Review
  2. Bacillus cereus PelAThe Journal of biological chemistry · 2026
    Article
  3. Article
  4. Extracellular matrix chemistry tunes bacterial biofilm metabolism and optimizes fitness.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. UnderstandingMicroorganisms · 2026
    Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Biofilm · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

François Le Mauff *Department of Microbiology and Immunology, Faculty of Medicine, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-0712-5837
Erum Razvi *Program in Molecular Medicine, Research Institute The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-5555-1438
Courtney ReichhardtDepartment of Microbiology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-1022-5110
Piyanka SivarajahProgram in Molecular Medicine, Research Institute The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-8386-9283
Matthew R ParsekDepartment of Microbiology, University of Washington, Seattle, WA, USA.
P Lynne HowellProgram in Molecular Medicine, Research Institute The Hospital for Sick Children, Toronto, ON, Canada. howell@sickkids.ca.ORCID http://orcid.org/0000-0002-2776-062X
Donald C SheppardDepartment of Microbiology and Immunology, Faculty of Medicine, McGill University, Montreal, QC, Canada. don.sheppard@mcgill.ca.ORCID http://orcid.org/0000-0001-8877-880X

Funding

The pel exopolysaccharide gene cluster of Pseudomonas aeruginosaR01AI077628 · NIAID · UNIVERSITY OF WASHINGTON · PI MATTHEW R. PARSEK, Daniel J Wozniak · 2009 to 2026
$7.1M
The biofilm matrix of P. aeruginosaR01AI143916 · NIAID · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL, PARSEK, MATTHEW R. · 2019 to 2023
$2.9M
Revisiting alginate paradigmsR01AI134895 · NIAID · OHIO STATE UNIVERSITY · PI WOZNIAK, DANIEL J · 2018 to 2022
$2.5M
CIHR FDN154327CIHR FDN159902NIAID NIH HHS R01 AI077628NIAID NIH HHS R01 AI134895NIAID NIH HHS R01 AI143916U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AI077628U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AI134895
6 · The paper itself

Abstract

The genetic capacity to synthesize the biofilm matrix exopolysaccharide Pel is widespread among Gram-negative and Gram-positive bacteria. However, its exact chemical structure has been challenging to determine. Using a Pseudomonas aeruginosa strain engineered to overproduce Pel, improvements to the isolation procedure, and selective hydrolysis with the glycoside hydrolase PelA

Indexed as

AcetylgalactosaminePolysaccharides, BacterialBiofilmsGalactosaminePolymersAcetylgalactosamineGalactosaminePolymersPolysaccharides, Bacterial

Identifiers

PMID35618750
PMCPMC9135694

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.