Evidence map›Paper›PMID 35618748›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2022

The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation.

Abbot R Laptook, Lina Chalak, Athina Pappas, Alexis Davis, Pablo J Sanchez, Krisa P Van Meurs, William Oh, Ross Sommers, Seetha Shankaran, Angelita M Hensman and 10 more

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Abbot R LaptookDepartment of Pediatrics, Women and Infants Hospital, Brown University, Providence, RI, USA. alaptook@wihri.org.ORCID 0000-0001-9848-3466
Lina ChalakDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Athina PappasDepartment of Pediatrics, Wayne State University, Detroit, MI, USA.
Alexis DavisDepartment of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.
Pablo J SanchezDepartment of Pediatrics, Nationwide Children's Hospital, The Ohio State College of Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.ORCID 0000-0003-2437-1247
Krisa P Van MeursDepartment of Pediatrics, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine and Lucile Packard Children's Hospital, Palo Alto, CA, USA.ORCID 0000-0002-9242-1480
William OhDepartment of Pediatrics, Women and Infants Hospital, Brown University, Providence, RI, USA.
Ross SommersNeonatology, Wellington Medical Center, Boca Raton, FL, USA.
Seetha ShankaranDepartment of Pediatrics, Wayne State University, Detroit, MI, USA.
Angelita M HensmanDepartment of Pediatrics, Women and Infants Hospital, Brown University, Providence, RI, USA.ORCID 0000-0003-3480-3373
Dwight J RouseDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Women and Infants Hospital, Brown University, Providence, RI, USA.
Scott McDonaldSocial, Statistical and Environmental Sciences Unit, RTI International, Research Triangle, NC, USA.
Abhik DasSocial, Statistical and Environmental Sciences Unit, RTI International, Rockville, MD, USA.
Ronald N GoldbergDepartment of Pediatrics, Duke University, Durham, NC, USA.
Namasivayam AmbalavananDivision of Neonatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Cynthia Gyamfi-BannermanDepartment of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY, USA.
Elizabeth A ThomDepartment of Biostatistics and Bioinformatics, George Washington University, Washington, DC, USA.
Rosemary D HigginsDepartment of Global and Community Health, George Mason University, Fairfax, VA, USA.ORCID 0000-0001-5590-9826
Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NRN)
Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network

Funding

Data Coord Ctr-NICHD Cooperative Multicenter Maternal Medicine Units Research NetU10HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI CLIFTON, REBECCA GERSNOVIEZ · 2009 to 2021
$174.2M
SARS-CoV-2 Vaccine Pregnancy RegistryU24HD036801 · NICHD · GEORGE WASHINGTON UNIVERSITY · PI Rebecca Gersnoviez Clifton · 2021 to 2026
$39.2M
Maternal-Fetal Medicine Units (MFMU) NetworkUG1HD040485 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Noelia Milena Modad Zork · 2016 to 2026
$3.6M
UofU Maternal-Fetal Medicine Units (MFMU) Network: Clinical CentersUG1HD034208 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Torri D Metz · 2016 to 2026
$3.4M
NICHD Maternal Fetal Medicine Units NetworkUG1HD027915 · NICHD · OHIO STATE UNIVERSITY · PI Maged Costantine · 2016 to 2026
$3.3M
NICHD Maternal-Fetal Medicine Units (MFMU) NetworkUG1HD087230 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HYAGRIV N SIMHAN · 2016 to 2026
$3.2M
NICHD Maternal-Fetal Medicine Units NetworksUG1HD027869 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALAN THEVENET N. TITA · 2016 to 2026
$3.0M
NICHD Neonatal Research NetworkUG1HD027904 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI MARON, JILL LAMANNA · 2016 to 2024
$2.1M
NICHD NIH HHS U10 HD036801NICHD NIH HHS U10HD036801NICHD NIH HHS U24 HD036801NICHD NIH HHS UG1 HD027869NICHD NIH HHS UG1 HD027904NICHD NIH HHS UG1HD027904NICHD NIH HHS UG1 HD027915NICHD NIH HHS UG1 HD034208NICHD NIH HHS UG1 HD040485NICHD NIH HHS UG1 HD087230
6 · The paper itself

Abstract

objectiveAssess if maternal betamethasone administration at 34-35 weeks accelerated neonatal amplitude integrated EEG (aEEG) maturation. STUDY

designNested, observational cohort in 7 centers participating in the Antenatal Late Preterm Steroid randomized trial. Up to 2 aEEGs were obtained in neonates born from 34

results58 neonates were enrolled (betamethasone, 28, placebo, 30). On aEEG 1, cycle frequency did not differ, but betamethasone exposed infants had a greater lower border voltage and a broader span. On aEEG 2, both groups displayed increases in lower border voltage.

conclusionsBetamethasone associated changes in lower border voltage support accelerated electrical activity. Further investigation is needed to understand the broader span.

Indexed as

BetamethasonePremature BirthCohort StudiesElectroencephalographyFemaleGestational AgeHumansInfant, NewbornPregnancyBetamethasone

Identifiers

PMID35618748
PMCPMC9699898

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.