Evidence map›Paper›PMID 35618745›Full record

ArticleNature communications2022

Enantioselective alkylative cross-coupling of unactivated aromatic C-O electrophiles.

Zishuo Zhang, Jintong Zhang, Quan Gao, Yu Zhou, Mingyu Yang, Haiqun Cao, Tingting Sun, Gen Luo, Zhi-Chao Cao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Atroposelective catalysis.Nature reviews. Chemistry · 2024
    Review
  5. The Versatile and StrategicChemical reviews · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zishuo Zhang *Anhui Province Engineering Laboratory for Green Pesticide Development and Application, College of Plant Protection, Anhui Agricultural University, Hefei, Anhui, 230036, China.
Jintong Zhang *Anhui Province Engineering Laboratory for Green Pesticide Development and Application, College of Plant Protection, Anhui Agricultural University, Hefei, Anhui, 230036, China.
Quan Gao *Anhui Province Engineering Laboratory for Green Pesticide Development and Application, College of Plant Protection, Anhui Agricultural University, Hefei, Anhui, 230036, China.
Yu ZhouInstitute of Physical Science and Information Technology, Anhui University, Hefei, 230601, China.
Mingyu YangSchool of Chemistry & Chemical Engineering, Shaanxi Normal University, Xi'an, Shaanxi, 710119, China.
Haiqun CaoAnhui Province Engineering Laboratory for Green Pesticide Development and Application, College of Plant Protection, Anhui Agricultural University, Hefei, Anhui, 230036, China.
Tingting SunAnhui Province Engineering Laboratory for Green Pesticide Development and Application, College of Plant Protection, Anhui Agricultural University, Hefei, Anhui, 230036, China.
Gen LuoInstitute of Physical Science and Information Technology, Anhui University, Hefei, 230601, China. luogen@ahu.edu.cn.ORCID 0000-0002-5297-6756
Zhi-Chao CaoAnhui Province Engineering Laboratory for Green Pesticide Development and Application, College of Plant Protection, Anhui Agricultural University, Hefei, Anhui, 230036, China. zc_cao@ahau.edu.cn.ORCID 0000-0002-5496-4425

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonpolar alkyl moieties, especially methyl group, are frequently used to modify bioactive molecules during lead optimization in medicinal chemistry. Thus transition-metal catalyzed alkylative cross-coupling reactions by using readily available and environmentally benign C-O electrophiles have been established as powerful tools to install alkyl groups, however, the C(sp

Indexed as

NickelCatalysisLigandsStereoisomerismLigandsNickel

Identifiers

PMID35618745
PMCPMC9135759

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.