ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022
Bioresorbable Nanostructured Chemical Sensor for Monitoring of pH Level In Vivo.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
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- Multiparametric Bioresorbable Sensor for Doxorubicin Detection via Molecularly Imprinted Synthetic Receptors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Review on Biodegradable Materials of Sustainable Soft Robotics and Electronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Multi-Level Perception Systems in Fusion of Lifeforms: Classification, Challenges and Future Conceptions.Sensors (Basel, Switzerland) · 2026Review
- Biodegradable Implantable Electronics with Wireless Technology for Real-Time Clinical Applications.Advanced healthcare materials · 2026Review
- MIP-Modified Porous Silicon Optical Sensor for Interleukin-6 Label-Free Quantification.Biosensors · 2025Article
- In vivo and in situ monitoring of doxorubicin pharmacokinetics with an implantable bioresorbable optical sensor.Science advances · 2025Article
- Recent Advances of Macrostructural Porous Silicon for Biomedical Applications.ACS applied materials & interfaces · 2025Review
- Reconfigurable Optical Sensor for Metal-Ion-Mediated Label-Free Recognition of Different Biomolecular Targets.ACS applied materials & interfaces · 2024Article
- Design and Development of Transient Sensing Devices for Healthcare Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Bioresorbable, wireless, passive sensors for continuous pH measurements and early detection of gastric leakage.Science advances · 2024Article
- Bioresorbable shape-adaptive structures for ultrasonic monitoring of deep-tissue homeostasis.Science (New York, N.Y.) · 2024Article
- Recent Advances in Fluorescent Probes for Cancer Biomarker Detection.Molecules (Basel, Switzerland) · 2024Review
- One-Dimensional Implantable Sensors for Accurately Monitoring Physiological and Biochemical Signals.Research (Washington, D.C.) · 2024Review
- Dual-Lifetime Referencing (Sensors (Basel, Switzerland) · 2023Article
- Beyond Tissue replacement: The Emerging role of smart implants in healthcare.Materials today. Bio · 2023Review
- Article
- An Ex Vivo Study of Wireless Linkage Distance between Implantable LC Resonance Sensor and External Readout Coil.Sensors (Basel, Switzerland) · 2022Article
- Bioresorbable Nanostructured Chemical Sensor for Monitoring of pH Level In Vivo.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Here, the authors report on the manufacturing and in vivo assessment of a bioresorbable nanostructured pH sensor. The sensor consists of a micrometer-thick porous silica membrane conformably coated layer-by-layer with a nanometer-thick multilayer stack of two polyelectrolytes labeled with a pH-insensitive fluorophore. The sensor fluorescence changes linearly with the pH value in the range 4 to 7.5 upon swelling/shrinking of the polymer multilayer and enables performing real-time measurements of the pH level with high stability, reproducibility, and accuracy, over 100 h of continuous operation. In vivo studies carried out implanting the sensor in the subcutis on the back of mice confirm real-time monitoring of the local pH level through skin. Full degradation of the pH sensor occurs in one week from implant in the animal model, and its biocompatibility after 2 months is confirmed by histological and fluorescence analyses. The proposed approach can be extended to the detection of other (bio)markers in vivo by engineering the functionality of one (at least) of the polyelectrolytes with suitable receptors, thus paving the way to implantable bioresorbable chemical sensors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.