Evidence map›Paper›PMID 35618633›Full record

ArticleJournal of advanced research2023

Multi-Probiotics ameliorate Major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation.

Peijun Tian, Renying Zou, Luyao Wang, Ying Chen, Xin Qian, Jianxin Zhao, Hao Zhang, Long Qian, Qun Wang, Gang Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of advanced research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Peijun TianState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
Renying ZouState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
Luyao WangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
Ying ChenState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
Xin QianState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.
Jianxin ZhaoState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China; (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, China.
Hao ZhangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China; (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, China; Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch, China.
Long QianThe Tinghu People's Hospital, Yancheng 224002, China.
Qun WangThe Tinghu People's Hospital, Yancheng 224002, China.
Gang WangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou 225004, China. Electronic address: wanggang@jiangnan.edu.cn.
Wei ChenState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122 PR China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMajor depressive disorder (MDD) is a leading global psychiatric disease. MDD is highly comorbid with gastrointestinal abnormalities, such as gut motility dysfunction. An effective strategy to manage depression and its accompanying gastrointestinal symptoms is warranted.

objectivesThree probiotic strains (Bifidobacterium breve CCFM1025, Bifidobacterium longum CCFM687, and Pediococcus acidilactici CCFM6432) had previously been validated in mice to possess antidepressant-like potential. This study investigated the potential psychotropic effects of a combined three-strain probiotic intervention for human MDD patients. The mechanism of action was further investigated in the stress-induced depression mice model.

methodsMDD patients were given a freeze-dried, mixed probiotic formula for four weeks. The patients' psychometric and gastrointestinal conditions were evaluated using clinical rating scales before and after treatment. Their gut microbiome was also analysed using 16S rRNA gene amplicon sequencing. The mechanisms underlying the beneficial probiotic effects were determined using a chronic stress-induced depressive mouse model.

resultsMulti-probiotics significantly reduced depression scores, and to a greater extent than the placebo (based on the Hamilton Depression Rating, Montgomery-Asberg Depression Rating, and Brief Psychiatric Rating Scales). Multi-probiotics also significantly improved the patients' gastrointestinal functions (based on self-evaluation using the Gastrointestinal Symptom Rating Scale). Serotonergic system modification was demonstrated as the key mechanism behind the probiotics' benefits for the brain and the gut.

conclusionOur findings suggest a novel and promising treatment to manage MDD and accompanying gut motility problems, and provide options for treating other gut-brain axis-related disorders.

Indexed as

Bifidobacterium longumMajor Depressive DisorderProbioticsAnimalsAntidepressive AgentsHumansMiceRNA, Ribosomal, 16SSyndromeAntidepressive AgentsRNA, Ribosomal, 16SDepressionGut motilityProbioticsSerotoninStress

Identifiers

PMID35618633
PMCPMC10006521

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.