ArticleBritish journal of anaesthesia2023
Connected consciousness after tracheal intubation in young adults: an international multicentre cohort study.
Article in British journal of anaesthesia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 48 citations in OpenAlex.
- Subanaesthetic doses of ketamine reduce but do not eliminate predictive coding responses: implications for mechanisms of sensory disconnection.British journal of anaesthesia · 2023Trial
- Accuracy of closed-loop and open-loop propofol delivery systems by bispectral index monitoring in breast surgery patients: a prospective randomized trial.Brazilian journal of anesthesiology (Elsevier)Trial
- Making brain monitoring routine: why processed EEG monitoring should be standard practice.Journal of clinical monitoring and computing · 2026Article
- Revisiting MAC as a static measure of anaesthesia: evidence for dynamic responses under isoflurane in male mice.British journal of anaesthesia · 2026Article
- Exploratory study of electroencephalogram markers of responsiveness to surgical noxious stimuli under propofol anaesthesia.BMC anesthesiology · 2026Article
- An experimental study of the effect of neuromuscular blockade on EEG-based measures of awareness.Scientific reports · 2026Article
- Sex-Based Differences in Hemodynamic Response to Anesthesia Type During TAVI and Early Transvalvular Gradient Changes.Journal of clinical medicine · 2025Article
- Changes in brain connectivity and neurovascular dynamics during dexmedetomidine-induced loss of consciousness.Communications biology · 2025Article
- Sex impacts on mismatch negativity under low-dose ketamine.British journal of anaesthesia · 2025Article
- Genetic Variation and Sex-Based Differences: Current Considerations for Anesthetic Management.Current issues in molecular biology · 2025Review
- The relationship of bispectral index values to conscious state: an analysis of two volunteer cohort studies.British journal of anaesthesia · 2025Article
- Noradrenergic suppression to reduce electroencephalographic arousal after intubation: a randomised, placebo-controlled trial.BJA open · 2025Article
- Maintenance of prehospital anaesthesia in trauma patients: inconsistencies and variability in practice.BJA open · 2025Article
- Preventive strategies for reducing intraoperative awareness due to errors in anesthetic drug delivery systems: a narrative review.Frontiers in pharmacology · 2025Review
- Brain health: A concern for anaesthesiologists and intensivists.European journal of anaesthesiology and intensive care · 2024Review
- Separation of responsive and unresponsive patients under clinical conditions: comparison of symbolic transfer entropy and permutation entropy.Journal of clinical monitoring and computing · 2024Article
- Hormonal basis of sex differences in anesthetic sensitivity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Brain state identification and neuromodulation to promote recovery of consciousness.Brain communications · 2024Review
- Study protocol: Cerebral characterization of sensory gating in disconnected dreaming states during propofol anesthesia using fMRI.Frontiers in neuroscience · 2024Article
- The nature of consciousness in anaesthesia.BJA open · 2023Review
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29 authors at 12 institutions in 6 countries.
Funding
Abstract
backgroundConnected consciousness, assessed by response to command, occurs in at least 5% of general anaesthetic procedures and perhaps more often in young people. Our primary objective was to establish the incidence of connected consciousness after tracheal intubation in young people aged 18-40 yr. The secondary objectives were to assess the nature of these responses, identify relevant risk factors, and determine their relationship to postoperative outcomes.
methodsThis was an international, multicentre prospective cohort study using the isolated forearm technique to assess connected consciousness shortly after tracheal intubation.
resultsOf 344 enrolled subjects, 338 completed the study (mean age, 30 [standard deviation, 6.3] yr; 232 [69%] female). Responses after intubation occurred in 37/338 subjects (11%). Females (13%, 31/232) responded more often than males (6%, 6/106). In logistic regression, the risk of responsiveness was increased with female sex (odds ratio [OR
conclusionsConnected consciousness occured after intubation in 11% of young adults, with females at increased risk. Continuous exposure to anaesthesia between induction of anaesthesia and tracheal intubation should be considered to reduce the incidence of connected consciousness. Further research is required to understand sex-related differences in the risk of connected consciousness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.