Evidence map›Paper›PMID 35618534›Full record

ArticleInternational journal of STD & AIDS2022

Viral load scale-up in south Sudan: Strategic implementation of tools to monitor HIV treatment success among people living with HIV.

Helen Chun, Anna Russell, Gordon Abe, Joel Katoro, Jackson Songok, Grace Lesuk, Habtamu Worku, Onyekachi Ukaejiofo, Dennis Lodiongo, Robert Olemukun and 5 more

Abstract read
In one paragraph

Article in International journal of STD & AIDS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Helen ChunDivision of Global HIV & TB, Center for Global Health, 1242Centers for Disease Control and Prevention, Atlanta, GA, USA.ORCID 0000-0002-1050-7361
Anna RussellDivision of Global HIV & TB, Center for Global Health, 1242Centers for Disease Control and Prevention, Atlanta, GA, USA.
Gordon AbeMinistry of Health, National Public Health Laboratory, Juba, South Sudan.
Joel KatoroDivision of Global HIV & TB, Center for Global Health, 1242Centers for Disease Control and Prevention, Juba, South Sudan.
Jackson SongokAMREF, Juba, South Sudan.
Grace LesukICAP at Columbia University, Juba, South Sudan.
Habtamu WorkuICAP at Columbia University, Juba, South Sudan.
Onyekachi UkaejiofoICAP at Columbia University, Juba, South Sudan.
Dennis LodiongoDivision of Global HIV & TB, Center for Global Health, 1242Centers for Disease Control and Prevention, Juba, South Sudan.
Robert OlemukunICAP at Columbia University, Juba, South Sudan.
Tat'Yana KenigsbergDivision of Healthcare Quality Promotion, 1242Centers for Disease Control and Prevention, Atlanta, GA, USA.
Shambel AragawICAP at Columbia University, Juba, South Sudan.
Lul Lojok DengMinistry of Health, National Public Health Laboratory, Juba, South Sudan.
Sudhir BungaDivision of Global HIV & TB, Center for Global Health, 1242Centers for Disease Control and Prevention, Juba, South Sudan.
Dennis EllenbergerDivision of Global HIV & TB, Center for Global Health, 1242Centers for Disease Control and Prevention, Atlanta, GA, USA.

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

introductionAs access to antiretroviral therapy (ART) for people with HIV (PWH) in the Republic of South Sudan (RSS) increases, viral load (VL) suppression is critical to protect global HIV response investments. We describe VL scale-up between 2017-2020 in the RSS President's Emergency Plan for AIDS Relief (PEPFAR)-supported program.

methodsPresident's Emergency Plan for AIDS Relief (PEPFAR) South Sudan developed a VL scale-up plan and tools spanning the VL cascade: pre-test, test and post-test and included assessment of clinical facility and laboratory readiness; clinical and laboratory forms and standard operating procedures for test ordering, specimen collection, processing, results return and utilization; procedures to map clients, monitor turn-around-times (TAT), and an electronic system to monitor VL performance.

resultsBetween 2017 to 2020, VL monitoring was established in 58 facilities, with 59,600 VL samples processed, and improvements in TAT (150-28 days) and rejection rates (1.9%-0.8%). VL documentation improved for dates of ART initiation, VL test request and dispatch, and HIV regimen. Total average time from high VL to repeat VL decreased from 15.9 months to 6.4 months in 2017 and 2019, respectively.

conclusionsA concerted approach to VL scale-up has been fundamental as South Sudan strives towards UNAIDS 95-95-95 targets for PWH on ART.

Indexed as

Acquired Immunodeficiency SyndromeAnti-HIV AgentsHIV InfectionsAnti-Retroviral AgentsHumansSouth SudanViral LoadAnti-HIV AgentsAnti-Retroviral Agentsantiretroviral therapydried blood spotenhanced adherence counselingHIVviral load

Identifiers

PMID35618534
PMCPMC9668367

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.