Evidence map›Paper›PMID 35618504›Full record

ArticleAtherosclerosis2022

Coronary artery calcium incidence and changes using direct plaque measurements: The MASALA study.

Harpreet S Bhatia, Feng Lin, Isac C Thomas, Julie Denenberg, Namratha R Kandula, Matthew J Budoff, Michael H Criqui, Alka M Kanaya

Open access · greenAbstract read
In one paragraph

Article in Atherosclerosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Harpreet S BhatiaDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, USA. Electronic address: hsbhatia@health.ucsd.edu.
Feng LinDepartment of Epidemiology & Biostatistics, University of California, San Francisco, USA.
Isac C ThomasDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, USA.
Julie DenenbergDivision of Preventive Medicine, Department of Family Medicine, University of California, San Diego, USA.
Namratha R KandulaDepartment of Medicine, Northwestern University Feinberg School of Medicine, USA.
Matthew J BudoffDivision of Cardiology, Lundquist Institute at Harbor-UCLA Medical Center, Los Angeles, USA.
Michael H CriquiDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, USA; Division of Preventive Medicine, Department of Family Medicine, University of California, San Diego, USA.
Alka M KanayaDepartment of Epidemiology & Biostatistics, University of California, San Francisco, USA; Department of Medicine, University of California, San Francisco, USA.
University of California San Diego · USUniversity of California, San Francisco · USNorthwestern University · USUCLA Medical Center · USUC San Diego Health System · US

Funding

Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Translational Research Core - Health Engagement & Action Translational (HEAT)P30DK092924 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI Alyce Sophia Adams, HILARY Kessler SELIGMAN · 2011 to 2026
$9.2M
UCSD Integrated Cardiovascular Epidemiology FellowshipT32HL079891 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Matthew A Allison · 2007 to 2026
$6.7M
Mediators of Atherosclerosis in South Asians Living in AmericaR01HL093009 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2010 to 2018
$5.4M
Social and Cultural Influences on Cardiovascular Risk in South AsiansR01HL120725 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KANDULA, NAMRATHA R · 2014 to 2017
$2.6M
Ectopic fat and atherosclerosis in South AsiansK24HL112827 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KANAYA, ALKA M. · 2013 to 2022
$1.2M
NCATS NIH HHS UL1 TR001872NCRR NIH HHS UL1 RR024131NHLBI NIH HHS K24 HL112827NHLBI NIH HHS R01 HL093009NHLBI NIH HHS R01 HL120725NHLBI NIH HHS T32 HL079891NIDDK NIH HHS P30 DK092924NIDDK NIH HHS P30 DK098722
6 · The paper itself

Abstract

BACKGROUND AND

aimsWe aimed to identify predictors of change in direct measures of coronary artery calcium (CAC) volume and density in South Asian participants.

methodsWe used data from participants in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study with prevalent CAC and direct measures of CAC by serial computed tomography (CT) exams (2010-2013, 2016-2018). We examined the distribution of incident CAC volume and peak density, as well as progression and identified risk factors for progression of change in volume and density in multivariable models.

resultsThe study cohort consisted of 102 participants with incident CAC and 285 with CAC progression. CAC volume and density were highest, and incident CAC was most common in the left anterior descending artery (LAD). The greatest progression in volume was in the right coronary artery and the greatest change in density was in the left main. In linear regression models for CAC progression adjusted for baseline density, volume, risk factors, smoking (β +190.1, p = 0.02), baseline volume (β +0.24 per mm

conclusionsIn this South Asian cohort, smoking was associated with CAC volume progression, while Lp(a) and exercise were associated with progression of peak CAC density.

Indexed as

AtherosclerosisCoronary Artery DiseasePlaque, AtheroscleroticVascular CalcificationAsian PeopleCalciumCalcium, DietaryCoronary VesselsHumansIncidenceRisk FactorsCalciumCalcium, DietaryCoronary artery calciumCoronary artery diseaselipoprotein(a)South asians

Identifiers

PMID35618504
PMCPMC9793717
OpenAlexW4280503781

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.