Evidence map›Paper›PMID 35618394›Full record

ReviewSeminars in nephrology2022

Glomerular Diseases of the Kidney Allograft: Toward a Precision Medicine Approach.

Francesca Zanoni, Pascale Khairallah, Krzysztof Kiryluk, Ibrahim Batal

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Francesca ZanoniDepartment of Medicine, Division of Nephrology, Columbia University Irving Medical Center, New York, NY.
Pascale KhairallahDepartment of Medicine, Division of Nephrology, Baylor College of Medicine, Houston, TX.
Krzysztof KirylukDepartment of Medicine, Division of Nephrology, Columbia University Irving Medical Center, New York, NY.
Ibrahim BatalDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY. Electronic address: ib2349@cumc.columbia.edu.
Columbia University Irving Medical Center · USBaylor College of Medicine · US

Funding

Genomics of glomerular diseaseRC2DK116690 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KIRYLUK, KRZYSZTOF, KRETZLER, MATTHIAS · 2018 to 2022
$5.0M
Genetics of IgA nephropathy by integrative network-based association studiesR01DK105124 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Krzysztof Kiryluk · 2015 to 2026
$4.8M
Kidney Precision Medicine Program (KPMP): Columbia AKI Recruitment SiteUH3DK114926 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BARASCH, JONATHAN M., BOMBACK, ANDREW STEPHEN · 2019 to 2021
$900k
NIDDK NIH HHS R01 DK105124NIDDK NIH HHS RC2 DK116690NIDDK NIH HHS UH3 DK114926
6 · The paper itself

Abstract

The continual development of potent immunosuppressive regimens has led to a decreased incidence of acute rejection and improvement of short-term kidney allograft survival. In contrast to acute rejection, glomerular diseases of the kidney allograft are being encountered more frequently and are emerging as leading causes of late kidney allograft failure. Although data on the pathogeneses of glomerular diseases in the kidney allograft are sparse, cumulative evidence suggests that post-transplant glomerular diseases may be the result of inherited predispositions and immunologic triggers. Although studying immunologic signals and performing genome-wide association studies are ideal approaches to tackle glomerular diseases in the kidney allograft, such studies are challenging because of the lack of adequately powered cohorts. In this review, we focus on the most commonly encountered recurrent and de novo glomerular diseases in the kidney allograft. We address the important advances made in understanding the immunopathology and genetic susceptibility of glomerular diseases in the native kidney and how to benefit from such knowledge to further our knowledge of post-transplant glomerular diseases. Defining genomic and immune predictors for glomerular diseases in the kidney allograft would support novel donor-recipient matching strategies and development of targeted therapies to ultimately improve long-term kidney allograft survival.

Indexed as

Kidney DiseasesKidney TransplantationAllograftsGenome-Wide Association StudyHumansKidneyPostoperative ComplicationsPrecision Medicinegenomicglomerular diseasesimmunopathologyKidney transplantation

Identifiers

PMID35618394
PMCPMC9139085
OpenAlexW4285066503

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.