Evidence map›Paper›PMID 35617964›Full record

ArticleImmunity2022

Dendritic cells can prime anti-tumor CD8

Brendan W MacNabb, Sravya Tumuluru, Xiufen Chen, James Godfrey, Darshan N Kasal, Jovian Yu, Marlieke L M Jongsma, Robbert M Spaapen, Douglas E Kline, Justin Kline

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 108 papers.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 154 citations in OpenAlex.

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  11. Tim-3-targeted vaccines overcome tumor immunosuppression and reduce cDC1 dependence to elicit potent anti-tumor immunity.Proceedings of the National Academy of Sciences of the United States of America · 2026
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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Brendan W MacNabbCommittee on Immunology, University of Chicago, Chicago, IL 60637, USA.
Sravya TumuluruCommittee on Cancer Biology, University of Chicago, Chicago, IL 60637, USA.
Xiufen ChenDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.
James GodfreyDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.
Darshan N KasalCommittee on Immunology, University of Chicago, Chicago, IL 60637, USA.
Jovian YuDepartment of Medicine, University of Chicago, Chicago, IL 60637, USA.
Marlieke L M JongsmaDepartment of Immunopathology, Sanquin Research, Amsterdam, the Netherlands; Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam, the Netherlands.
Robbert M SpaapenDepartment of Immunopathology, Sanquin Research, Amsterdam, the Netherlands; Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam, the Netherlands.
Douglas E KlineCommittee on Immunology, University of Chicago, Chicago, IL 60637, USA.
Justin KlineCommittee on Immunology, University of Chicago, Chicago, IL 60637, USA; Committee on Cancer Biology, University of Chicago, Chicago, IL 60637, USA; Department of Medicine, University of Chicago, Chicago, IL 60637, USA. Electronic address: jkline@medicine.bsd.uchicago.edu.
University of Chicago · USSanquin · NL

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1M
INTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7M
Characterization of a T cell dysfunctional state induced in mice with AMLR01CA166770 · NCI · UNIVERSITY OF CHICAGO · PI KLINE, JUSTIN P. · 2012 to 2016
$1.6M
NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA166770NIAID NIH HHS T32 AI007090
6 · The paper itself

Abstract

Antigen cross-presentation, wherein dendritic cells (DCs) present exogenous antigen on major histocompatibility class I (MHC-I) molecules, is considered the primary mechanism by which DCs initiate tumor-specific CD8

Indexed as

Dendritic CellsNeoplasmsAntigen PresentationAntigens, NeoplasmBandagesCD8-Positive T-LymphocytesCross-PrimingHistocompatibility Antigens Class IHumansMajor Histocompatibility ComplexPeptidesAntigens, NeoplasmHistocompatibility Antigens Class IPeptidesantigen presentationanti-tumor immunitydendritic cellMHC cross-dressing

Identifiers

PMID35617964
PMCPMC9883788
OpenAlexW4281479110

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.