Evidence map›Paper›PMID 35617882›Full record

ArticleEpidemics2022

Complex model calibration through emulation, a worked example for a stochastic epidemic model.

Michael Dunne, Hossein Mohammadi, Peter Challenor, Rita Borgo, Thibaud Porphyre, Ian Vernon, Elif E Firat, Cagatay Turkay, Thomas Torsney-Weir, Michael Goldstein and 3 more

Open access · goldAbstract read
In one paragraph

Article in Epidemics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Cross-validation-based sequential design for stochastic models.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
    Article
  3. Emulating computer models with high-dimensional count output.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 3 countries.

Michael DunneCollege of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK.
Hossein MohammadiCollege of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK.
Peter ChallenorCollege of Engineering, Mathematics and Physical Sciences, University of Exeter, Exeter, UK.
Rita BorgoDepartment of Informatics, King's College London, London, UK.
Thibaud PorphyreLaboratoire de Biométrie et Biologie Evolutive, VetAgro Sup, Marcy l'Etoile, France.
Ian VernonDepartment of Mathematical Sciences, Durham University, Durham, UK.
Elif E FiratDepartment of Computer Science, University of Nottingham, Nottingham, UK.
Cagatay TurkayCentre for Interdisciplinary Methodologies, University of Warwick, Coventry, UK.
Thomas Torsney-WeirVRVis Zentrum für Virtual Reality und Visualisierung Forschungs-GmbH, Vienna, Austria.
Michael GoldsteinDepartment of Mathematical Sciences, Durham University, Durham, UK.
Richard ReeveBoyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Hui FangDepartment of Computer Science, Loughborough University, Loughborough, UK.
Ben SwallowSchool of Mathematics and Statistics, University of Glasgow, Glasgow, UK. Electronic address: ben.swallow@glasgow.ac.uk.
University of Exeter · GBDurham University · GBDépartement Santé Animale · FRKing's College London · GBLoughborough University · GBUniversity of Glasgow · GBUniversity of Nottingham · GBUniversity of Warwick · GBVetAgro Sup · FRVRVis GmbH (Austria) · AT

Funding

Wellcome Trust 218261/Z/19/Z
6 · The paper itself

Abstract

Uncertainty quantification is a formal paradigm of statistical estimation that aims to account for all uncertainties inherent in the modelling process of real-world complex systems. The methods are directly applicable to stochastic models in epidemiology, however they have thus far not been widely used in this context. In this paper, we provide a tutorial on uncertainty quantification of stochastic epidemic models, aiming to facilitate the use of the uncertainty quantification paradigm for practitioners with other complex stochastic simulators of applied systems. We provide a formal workflow including the important decisions and considerations that need to be taken, and illustrate the methods over a simple stochastic epidemic model of UK SARS-CoV-2 transmission and patient outcome. We also present new approaches to visualisation of outputs from sensitivity analyses and uncertainty quantification more generally in high input and/or output dimensions.

Indexed as

COVID-19EpidemicsCalibrationHumansSARS-CoV-2UncertaintyCalibrationHistory matchingSEIRStochastic epidemic modelUncertainty quantification

Identifiers

PMID35617882
PMCPMC9109972
OpenAlexW4280611486

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.