ArticleScience (New York, N.Y.)2022
A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy.
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Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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78citing papers in PubMed
17.9field-weighted citation impact, top 1% of its field
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78 citing papers in PubMed, 237 citations in OpenAlex.
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- Wearable Sensing for Clinical Physiology Monitoring: Emerging Paradigms.Physiology (Bethesda, Md.) · 2026Review
- Computational Insights Into Smart Bioelectronics in Digital Health Care (2020-2024): Topic Modeling Study.JMIR medical informatics · 2026Review
- A wearable non-invasive sonogenetic pacemaker.Nature biomedical engineering · 2026Article
- Three-dimensional printing of multilayer stretchable electronics with inclined interconnect accesses.Nature communications · 2026Article
- Reconfigurable Spoof Plasmonic Skyrmion Electronics for Deformation-Invariant Multimode Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Critical point-based wireless sensors enabling tiny perturbation detection.Science advances · 2026Article
- Soft, Flexible, and Stretchable Platforms for Tissue-Interfaced Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Emerging Triboelectric Nanogenerators for In-Body Implantation.Small methods · 2026Review
- Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Autonomous Microrobots for Spatiotemporally Active Therapeutic Delivery and Controlled Release.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Soft bioelectronics for wireless drug delivery: programmable, minimally invasive and closed-loop therapeutics.npj soft matter · 2026Review
- Emergency delivery of particulate drugs by active ejection using in vivo wireless devices.Nature biomedical engineering · 2026Article
- Biodegradable Implantable Electronics with Wireless Technology for Real-Time Clinical Applications.Advanced healthcare materials · 2026Review
- Multifunctional Biomedical Devices with Closed-Loop Systems for Precision Therapy.Advanced healthcare materials · 2025Review
- Autonomous Implants.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Consumer-grade wearable devices in arrhythmia diagnostics for clinicians: where we are and where we are going.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2025Review
- Optimization Design of Haptic Units for Perception Feedback Interfaces Based on Vibrotactile Amplitude Modulation.Biomimetics (Basel, Switzerland) · 2025Article
- Article
18 more citing papers are in PubMed but not listed here.
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Authors and funding
49 authors at 6 institutions in 3 countries.
Yeon Sik Choi *Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-3813-3442
Hyoyoung Jeong *Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-1808-7824
Rose T Yin *Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0001-5887-9212
Raudel AvilaDepartment of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA.
Anna PfennigerFeinberg School of Medicine, Cardiology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-7812-0860
Jaeyoung YooCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-0934-4718
Jong Yoon LeeCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-1626-7669
Andreas TzavelisCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-0750-5007
Young Joong LeeCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-2096-2261
Sheena W ChenDepartment of General Surgery, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0002-8278-3517
Helen S KnightDepartment of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0002-2129-0401
Seungyeob KimCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-7375-4821
Hak-Young AhnCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-5441-1054
Grace WickersonCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-1561-8009
Abraham Vázquez-GuardadoCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-0648-5921
Elizabeth Higbee-DempseyDevelopmental Therapeutics Core, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-4122-7565
Bender A RussoDepartment of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0002-4232-1342
Michael A NapolitanoDepartment of General Surgery, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0002-0835-6453
Timothy J HolleranDepartment of General Surgery, The George Washington University, Washington, DC 20052, USA.
Leen Abdul RazzakCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-3097-6974
Alana N MiniovichDepartment of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0002-7183-6839
Geumbee LeeCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.
Beth GeistFeinberg School of Medicine, Cardiology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0002-2440-1584
Brandon KimSibel Health, Niles, IL 60714, USA.ORCID 0000-0002-8174-3214
Shuling HanComprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Jaclyn A BrennanDepartment of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0002-0757-546X
Kedar ArasDepartment of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.ORCID 0000-0002-9898-1462
Sung Soo KwakCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-2625-2471
Joohee KimCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-0294-9565
Emily Alexandria WatersDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-3479-6054
Xiangxing YangDepartment of Electrical and Computer Engineering, University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0002-6099-1374
Amy BurrellFeinberg School of Medicine, Cardiology, Northwestern University, Chicago, IL 60611, USA.
Keum San ChunDepartment of Electrical and Computer Engineering, University of Texas at Austin, Austin, TX 78712, USA.ORCID 0000-0001-5695-5816
Claire LiuCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-4308-389X
Changsheng WuCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.
Alina Y RweiDepartment of Chemical Engineering, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, Netherlands.
Alisha N SpannCenter for Advanced Molecular Imaging, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-7461-7543
Anthony BanksCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-0509-0370
David JohnsonFeinberg School of Medicine, Cardiology, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-9033-9590
Zheng Jenny ZhangComprehensive Transplant Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.ORCID 0000-0001-6469-5778
Chad R HaneyDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0001-5981-2925
Sung Hun JinCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-1799-7743
Alan Varteres SahakianDepartment of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0003-3090-0328
Yonggang HuangCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-0483-8359
Gregory D TrachiotisDepartment of Cardiothoracic Surgery, Veteran Affairs Medical Center, Washington, DC 20422, USA.ORCID 0000-0003-2403-905X
Bradley P KnightFeinberg School of Medicine, Cardiology, Northwestern University, Chicago, IL 60611, USA.
Rishi K AroraFeinberg School of Medicine, Cardiology, Northwestern University, Chicago, IL 60611, USA.
Igor R EfimovQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-1483-5039
John A RogersCenter for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.ORCID 0000-0002-3830-5980
Northwestern University · USGeorge Washington University · USThe University of Texas at Austin · USDelft University of Technology · NLSibel (United States) · USVeterans Health Administration · US
Funding
Northwestern University Clinical and Translational Science Institute (NUCATS)KL2TR001424 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHARMA, LEENA · 2015 to 2023
$8.1MNew and Disruptive Therapeutic Approaches to Target Fundamental Molecular Mechanisms Underlying Atrial FibrillationR35HL161249 · NHLBI · UNIVERSITY OF CHICAGO · PI Rishi Arora · 2022 to 2026
$5.1MThe identification and pathophysiology of non-infarcted but injured myocardium in the post-ischemic heartR01HL152712 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARORA, RISHI, ZHAO, MING · 2021 to 2024
$3.0MHigh-Definition Conformal Electronics for VT/VFR01HL141470 · NHLBI · NORTHWESTERN UNIVERSITY · PI EFIMOV, IGOR R · 2019 to 2022
$2.5MPathophysiological Significance of Atrial Fibrillation Electrogram PatternsR01HL125881 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARORA, RISHI · 2015 to 2019
$2.4MOxidative stress contributes to atrial fibrillation by causing remodeling of the autonomic nervous systemR01HL140061 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARORA, RISHI · 2018 to 2021
$2.3MSkin-like, stretchable, and wearable sensors for monitoring QT interval and hemodynamic variables in Atrial FibrillationF30HL157066 · NHLBI · NORTHWESTERN UNIVERSITY · PI TZAVELIS, ANDREAS · 2021 to 2025
$246kA Fully Biodegradable, Implantable, Wireless, Battery-free, Miniaturized Cardiac Pacemaker with Closed-loop System for Neonatal and Pediatric PatientsK99HL155844 · NHLBI · NORTHWESTERN UNIVERSITY · PI CHOI, YEONSIK · 2021 to 2022
$206kRole of epicardial adiposity as a local mediator of VT/VF dynamics in donor human heartsK99HL148523 · NHLBI · GEORGE WASHINGTON UNIVERSITY · PI ARAS, KEDAR KIRTIKUMAR · 2020 to 2021
$198kNCATS NIH HHS KL2 TR001424NHLBI NIH HHS F30 HL157066NHLBI NIH HHS K99 HL148523NHLBI NIH HHS K99 HL155844NHLBI NIH HHS R01 HL125881NHLBI NIH HHS R01 HL140061NHLBI NIH HHS R01 HL141470NHLBI NIH HHS R01 HL152712NHLBI NIH HHS R35 HL161249
Abstract
Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices.
Indexed as
Absorbable ImplantsCardiac Pacing, ArtificialPacemaker, ArtificialPostoperative CareWireless TechnologyAnimalsDogsHeart RateHumansRats
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.