ArticleScience (New York, N.Y.)2022
Catalyst-controlled site-selective methylene C-H lactonization of dicarboxylic acids.
Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 95 citations in OpenAlex.
- Article
- Catalyst-controlled site-selective dehydrogenation, a stepping stone for C-H oxidations in complex terpenes synthesis.Nature communications · 2026Article
- Transition Metal-Catalyzed Direct C(spChemical reviews · 2026Review
- Desymmetrization of Malonic Monoesters and Malonic Acids via Enantioselective Catalytic C(spAngewandte Chemie (International ed. in English) · 2026Article
- The role of 1,4-palladium migration in C(spRSC advances · 2025Review
- From Mono-Accounts of chemical research · 2025Review
- Transition-Metal-Catalyzed C(spTopics in current chemistry (Cham) · 2025Review
- A Schiff-Base Molecular Probe for Selective Fluorescence Sensing of Maleic Acid with Recognition of Maleic Acid in Food Additives and Cell Imaging.Journal of fluorescence · 2025Article
- Divergent Kinetic/Thermodynamic Selectivity in Palladium(II)-Mediated C-H Activation to Form 5- and 6-Membered Palladacycles.Journal of the American Chemical Society · 2025Article
- Palladium-Catalyzed Methylene β-C-H Fluorination of Native Amides.Journal of the American Chemical Society · 2025Article
- Catalyst-Controlled Chemoselective γ-C(spJournal of the American Chemical Society · 2024Article
- Versatile Copper-Catalyzed γ-C(spJournal of the American Chemical Society · 2024Article
- Palladium-catalysed methylene C(Nature synthesis · 2024Article
- Palladium (II)-Catalyzed C-H Activation with Bifunctional Ligands: From Curiosity to Industrialization.Angewandte Chemie (International ed. in English) · 2024Review
- Anthraquinone-based covalent organic framework as a recyclable direct hydrogen atom transfer photocatalyst for C-H functionalization.Chemical science · 2024Article
- Ligand-Enabled γ-C(spJournal of the American Chemical Society · 2023Article
- Ligand-Enabled Double γ-C(spAngewandte Chemie (International ed. in English) · 2023Article
- Access to unsaturated bicyclic lactones by overriding conventional C(spNature chemistry · 2023Article
- A tautomerized ligand enabled meta selective C-H borylation of phenol.Nature communications · 2023Article
- Synthesis of β,γ-Unsaturated Aliphatic Acids via Ligand-Enabled Dehydrogenation.Journal of the American Chemical Society · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Catalyst-controlled site-selective activation of β- and γ-methylene carbon-hydrogen (C-H) bonds of free carboxylic acids is a long-standing challenge. Here we show that, with a pair of palladium catalysts assembled with quinoline-pyridone ligands of different chelate ring sizes, it is possible to perform highly site-selective monolactonization reactions with a wide range of dicarboxylic acids, generating structurally diverse and synthetically useful γ- and δ-lactones via site-selective β- or γ-methylene C-H activation. The remaining carboxyl group serves as a versatile linchpin for further synthetic applications, as demonstrated by the total synthesis of two natural products, myrotheciumone A and pedicellosine, from abundant dicarboxylic acids.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.