Evidence map›Paper›PMID 35617212›Full record

ReviewPLoS pathogens2022

Overcoming pH defenses on the skin to establish infections.

Flavia G Costa, Alexander R Horswill

Open access · goldAbstract readReview
In one paragraph

Review in PLoS pathogens, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. The human skin microbiome in health.Journal of the American Academy of Dermatology · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Antibiotics (Basel, Switzerland) · 2023
    Review
  12. Article
  13. The Interkingdom Interaction withJournal of microbiology and biotechnology · 2023
    Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Flavia G CostaDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America.
Alexander R HorswillDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America.ORCID 0000-0002-5568-0096
University of Colorado Denver · USVA Eastern Colorado Health Care System · US

Funding

Quorum sensing, diversity and skin inflammationR01AI153185 · NIAID · UNIVERSITY OF COLORADO DENVER · PI GALLO, RICHARD L, HORSWILL, ALEXANDER R · 2020 to 2024
$3.2M
Quorum Sensing Dependent Interactions with Biofilms and Innate Immunity DefensesI01BX002711 · VA · VA EASTERN COLORADO HEALTH CARE SYSTEM · PI ALEXANDER R HORSWILL · 2015 to 2026
–
BLRD VA I01 BX002711NIAID NIH HHS R01 AI153185
6 · The paper itself

Abstract

Skin health is influenced by the composition and integrity of the skin barrier. The healthy skin surface is an acidic, hypertonic, proteinaceous, and lipid-rich environment that microorganisms must adapt to for survival, and disruption of this environment can result in dysbiosis and increase risk for infectious diseases. This work provides a brief overview of skin barrier function and skin surface composition from the perspective of how the most common skin pathogen, Staphylococcus aureus, combats acid stress. Advancements in replicating this environment in the laboratory setting for the study of S. aureus pathogenesis on the skin, as well as future directions in this field, are also discussed.

Indexed as

Staphylococcal InfectionsStaphylococcus aureusDysbiosisHumansHydrogen-Ion ConcentrationSkin

Identifiers

PMID35617212
PMCPMC9135183
OpenAlexW4281674406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.