Evidence map›Paper›PMID 35617115›Full record

ArticleeLife2022

Toward the cellular-scale simulation of motor-driven cytoskeletal assemblies.

Wen Yan, Saad Ansari, Adam Lamson, Matthew A Glaser, Robert Blackwell, Meredith D Betterton, Michael Shelley

Abstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Motor-Assisted Co-Migration of Intracellular Organelles and Microtubules as a Mechanism for Directed Cargo Transport.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  3. Form and function in biological filaments: a physicist's review.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Microscopic interactions control a structural transition in active mixtures of microtubules and molecular motors.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  10. ADP release can explain spatially-dependent kinesin binding times.bioRxiv : the preprint server for biology · 2023
    Article
  11. Article
  12. Modeling membrane reshaping driven by dynamic protein assemblies.Current opinion in structural biology · 2023
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wen YanCenter for Computational Biology, Flatiron Institute, New York, United States.ORCID 0000-0002-9189-0840
Saad AnsariDepartment of Physics, University of Colorado Boulder, Boulder, United States.
Adam LamsonCenter for Computational Biology, Flatiron Institute, New York, United States.ORCID 0000-0003-2616-2801
Matthew A GlaserDepartment of Physics, University of Colorado Boulder, Boulder, United States.ORCID 0000-0002-8366-5598
Robert BlackwellCenter for Computational Biology, Flatiron Institute, New York, United States.
Meredith D BettertonCenter for Computational Biology, Flatiron Institute, New York, United States.ORCID 0000-0002-5430-5518
Michael ShelleyCenter for Computational Biology, Flatiron Institute, New York, United States.

Funding

Mechanisms of Kinesin-5 Motors in Mitotic Spindle AssemblyR01GM124371 · NIGMS · UNIVERSITY OF COLORADO · PI BETTERTON, MEREDITH · 2018 to 2021
$1.3M
NIGMS NIH HHS R01 GM124371
6 · The paper itself

Abstract

The cytoskeleton - a collection of polymeric filaments, molecular motors, and crosslinkers - is a foundational example of active matter, and in the cell assembles into organelles that guide basic biological functions. Simulation of cytoskeletal assemblies is an important tool for modeling cellular processes and understanding their surprising material properties. Here, we present

Indexed as

Models, BiologicalMolecular Motor ProteinsComputer SimulationCytoskeletonMicrotubulesMolecular Motor Proteinscomputational biologyconstrained optimizationmicrotubulemotor proteinnoneparallel computingsystems biology

Identifiers

PMID35617115
PMCPMC9135453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.