Evidence map›Paper›PMID 35616874›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2022

Sex-Selective Increase of IGF-2 Expression in the Hypoxic Guinea Pig Placenta of Growth-Restricted Fetuses.

Emad A Elsamadicy, Loren P Thompson

Abstract read
PubMed Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Emad A ElsamadicyDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Loren P ThompsonDepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. lthompson1@umm.edu.ORCID 0000-0003-1693-3617
University of Maryland, Baltimore · US

Funding

Impact of Prenatal Hypoxia on Mitochondrial Function of Offspring HeartsR01HL126859 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI ALBRECHT, EUGENE D. · 2015 to 2022
$3.7M
NHLBI NIH HHS R01 HL126859
6 · The paper itself

Abstract

Chronic hypoxia can cause fetal growth restriction (FGR) through placental dysfunction. Insulin-like growth factors (IGFs), such as IGF-2, play a major role in preservation of placental growth and function. We investigated the effects of chronic hypoxia and sex on protein expression of the IGF-2 pathway in placentas selected from asymmetric-FGR fetuses. Time-mated pregnant guinea pigs were assigned to normoxia (NMX, 21% O

Indexed as

Insulin-Like Growth Factor IIPlacentaAnimalsFemaleFetal Growth RetardationFetusGuinea PigsHumansHypoxiaMalePhosphatidylinositol 3-KinasesPregnancyProliferating Cell Nuclear AntigenProto-Oncogene Proteins c-aktInsulin-Like Growth Factor IIPhosphatidylinositol 3-KinasesProliferating Cell Nuclear AntigenProto-Oncogene Proteins c-aktFetal growth restrictionGuinea pigHypoxiaIGFPlacental growth factorsSexual dimorphism

Identifiers

PMID35616874
OpenAlexW4281570966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.