Evidence map›Paper›PMID 35616807›Full record

ArticleMolecular and cellular biochemistry2022

Hsa_circ_0006732 regulates colorectal cancer cell proliferation, invasion and EMT by miR-127-5p/RAB3D axis.

Tao Yang, Jufeng Sun, Wei Wang, Dongsheng Li, Xianxu Yang, Ang Jia, Yinda Ma, Zhongkai Fan

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Circular RNAs and Cancers.Advances in experimental medicine and biology · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tao YangThe First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, 510000, China.
Jufeng SunOrthopedic Department, First Affiliated Hospital of Jinzhou Medical University, No.2 Renmin Street, Jinzhou, 121000, China.
Wei WangDepartment of General Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121010, China.
Dongsheng LiDepartment of General Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, 121010, China.
Xianxu YangOrthopedic Department, First Affiliated Hospital of Jinzhou Medical University, No.2 Renmin Street, Jinzhou, 121000, China.
Ang JiaOrthopedic Department, First Affiliated Hospital of Jinzhou Medical University, No.2 Renmin Street, Jinzhou, 121000, China.
Yinda MaOrthopedic Department, First Affiliated Hospital of Jinzhou Medical University, No.2 Renmin Street, Jinzhou, 121000, China.
Zhongkai FanThe First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, 510000, China. zhongkaifan1@163.com.ORCID http://orcid.org/0000-0002-5889-2123

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) remains a malignancy tumor with high metastasis and poor prognosis. We aimed to explore the effect of circular RNA (circRNA) hsa_circ_0006732 in the progression of CRC. Hsa_circ_0006732 expression in CRC tissues and cell lines were detected using qRT-PCR. The relationship between hsa_circ_0006732 expression and clinicopathologic characteristics of patients with CRC was analyzed. Loss-of-function assay was conducted to determine the regulatory effect of hsa_circ_0006732 on CRC cell proliferation, migration and invasion by using the CCK-8, wound-healing assay and transwell assays. Protein expression changes on epithelial mesenchymal transition (EMT)-related factors were detected by western blotting. The downstream signaling pathway was investigated by bioinformatics, dual-luciferase reporter assay. Rescue assay was further examined for prediction validation. It was found that hsa_circ_0006732 was highly expressed in CRC tissues and cell lines. Downregulation of hsa_circ_0006732 suppressed the proliferation, migration, invasion and EMT of CRC cells. Further mechanistic investigations proved that hsa_circ_0006732 functioned as a competitive endogenous RNA (ceRNA) by directly sponging of miR-127-3p, which further affected the expression of Ras-related protein Rab-3D (Rab3D). Taken together, these findings indicated that hsa_circ_0006732 might be an oncogene in CRC through the regulation of the miR-127-5p/RAB3D axis. Thus, hsa_circ_0006732 might serve as a potential therapeutic target for the treatment of CRC.

Indexed as

Colorectal NeoplasmsMicroRNAsrab3 GTP-Binding ProteinsRNA, CircularCell Line, TumorCell ProliferationEpithelial-Mesenchymal TransitionHumansMicroRNAsMIRN127 microRNA, humanRAB3D protein, humanrab3 GTP-Binding ProteinsRNA, CircularColorectal cancerEMThsa_circ_0006732miR-127-5pRAB3D

Identifiers

PMID35616807

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.