Evidence map›Paper›PMID 35616700›Full record

ArticleThe British journal of radiology2023

Overcoming challenges of translating deep-learning models for glioblastoma: the ZGBM consortium.

Haris Shuaib, Gareth J Barker, Peter Sasieni, Enrico De Vita, Alysha Chelliah, Roman Andrei, Keyoumars Ashkan, Erica Beaumont, Lucy Brazil, Chris Rowland-Hill and 10 more

Abstract read
In one paragraph

Article in The British journal of radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Haris ShuaibGuy's & St Thomas' NHS Foundation Trust, King's College, London, United Kingdom.ORCID 0000-0001-6975-5960
Gareth J BarkerKing's College London, London, United Kingdom.
Peter SasieniKing's College London, London, United Kingdom.
Enrico De VitaKing's College London, London, United Kingdom.
Alysha ChelliahKing's College London, London, United Kingdom.
Roman AndreiThe Oncology Institute "Prof. Dr. Ion Chiricuţă" Cluj-Napoca, Cluj-Napoca, Romania.
Keyoumars AshkanKing's College Hospital NHS Foundation Trust, London, United Kingdom.
Erica BeaumontLancashire Teaching Hospitals NHS Foundation Trust, Lancashire, United Kingdom.
Lucy BrazilGuy's & St Thomas' NHS Foundation Trust, King's College, London, United Kingdom.
Chris Rowland-HillHull & East Yorkshire Hospitals NHS Trust, England, United Kingdom.
Yue Hui LauKing's College Hospital NHS Foundation Trust, London, United Kingdom.
Aysha LuisKing's College London, London, United Kingdom.
James PowellVelindre University NHS Trust, Wales, United Kingdom.
Angela SwampillaiGuy's & St Thomas' NHS Foundation Trust, King's College, London, United Kingdom.
Sean TenantThe Christie NHS Foundation Trust, Manchester, United Kingdom.
Stefanie C ThustNational Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, London, United Kingdom.
Stephen WastlingNational Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, London, United Kingdom.
Tom YoungGuy's & St Thomas' NHS Foundation Trust, King's College, London, United Kingdom.
Thomas C BoothGuy's & St Thomas' NHS Foundation Trust, King's College, London, United Kingdom.
ZGBM consortium

Funding

Cancer Research UK 27047Cancer Research UK 28832Wellcome Trust
6 · The paper itself

Abstract

objectiveTo report imaging protocol and scheduling variance in routine care of glioblastoma patients in order to demonstrate challenges of integrating deep-learning models in glioblastoma care pathways. Additionally, to understand the most common imaging studies and image contrasts to inform the development of potentially robust deep-learning models.

methodsMR imaging data were analysed from a random sample of five patients from the prospective cohort across five participating sites of the ZGBM consortium. Reported clinical and treatment data alongside DICOM header information were analysed to understand treatment pathway imaging schedules.

resultsAll sites perform all structural imaging at every stage in the pathway except for the presurgical study, where in some sites only contrast-enhanced

conclusionThe imaging protocol and scheduling varies across the UK, making it challenging to develop machine-learning models that could perform robustly at other centres. Structural imaging is performed most consistently across all centres. ADVANCES IN KNOWLEDGE: Successful translation of deep-learning models will likely be based on structural post-treatment imaging unless there is significant effort made to standardise non-structural or peri-operative imaging protocols and schedules.

Indexed as

Brain NeoplasmsDeep LearningGlioblastomaHumansMagnetic Resonance ImagingProspective StudiesRetrospective Studies

Identifiers

PMID35616700
PMCPMC10997010

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.