Evidence map›Paper›PMID 35616681›Full record

ArticleAnti-cancer agents in medicinal chemistry2024

Apoptosis-inducing Metabolite from Marine Mangrove Actinobacteria VITGAP173.

Ajitha Gomathi, Manikandan Alagumuthu, Pavan K J G Sai, Harishkumar Madhyastha, Rama Jayaraj, Gothandam K Muthukailannan

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Article in Anti-cancer agents in medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Ajitha GomathiDepartment of Biotechnology, School of BioSciences and Technology, Vellore Institute of Technology (VIT), Vellore - 14, Tamil Nadu, India.
Manikandan AlagumuthuM.S. Ramaiah College of Arts, Science and Commerce, Bengaluru-560054, Karnataka, India.
Pavan K J G SaiDepartment of Biotechnology, School of BioSciences and Technology, Vellore Institute of Technology (VIT), Vellore - 14, Tamil Nadu, India.
Harishkumar MadhyasthaDepartment of Applied Physiology, Faculty of Medicine, University of Miyazaki, Miyazaki. 889-1692, Japan.
Rama JayarajNorthern Territory Institute of Research and Training, Darwin, Northern Territory-0810, Australia.
Gothandam K MuthukailannanDepartment of Biotechnology, School of BioSciences and Technology, Vellore Institute of Technology (VIT), Vellore - 14, Tamil Nadu, India.
Vellore Institute of Technology University · INOxford Dental College and Hospital · INUniversity of Miyazaki · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMarine actinobacteria have proven to be a remarkable source of bioactive metabolites.

methodsThe present study focused on the isolation of anticancer metabolites from marine actinobacteria.

resultsBioassay-guided fractionation was followed to identify the bioactive metabolites from crude ethyl acetate extract of VITGAP173, which yielded four fractions. Fraction B exhibited the highest cytotoxic activity against MCF-7 cell lines among the four fractions. Further structural characterization of the fraction was done by FTIR and NMR spectroscopy. The fraction-2 induced cytotoxicity against MCF-7 cell lines and the half maximal inhibition (IC

conclusionThe present findings suggested the apoptosis-inducing potential of fraction-2 in breast cancer therapy.

Indexed as

Antineoplastic AgentsApoptosisDose-Response Relationship, DrugDrug Screening Assays, AntitumorActinobacteriaActivating Transcription Factor 4Cell ProliferationHumansMCF-7 CellsMolecular StructureReactive Oxygen SpeciesStructure-Activity RelationshipTranscription Factor CHOPTumor Cells, CulturedActivating Transcription Factor 4Antineoplastic AgentsATF4 protein, humanReactive Oxygen SpeciesTranscription Factor CHOPactinobacteriaapoptosisbioactive fractioncytotoxicER stress.Mangrove

Identifiers

PMID35616681
OpenAlexW4281565824

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.