ReviewThe British journal of radiology2022
Volumetric modulated arc therapy (VMAT): a review of clinical outcomes-what is the clinical evidence for the most effective implementation?
Review in The British journal of radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Proton Beam Therapy in Gynecological Cancers: A Systematic Review of Indications, Complications, and Limitations.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Helical intensity-modulated radiation therapy vs. C-arm-based volumetric modulated arc therapy for sinonasal tumours: organ at risk sparing and treatment efficiency.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- Introducing a novel prediction index for treatment quality of gamma knife and stereotactic-based radiotherapy: Nabaa Efficiency Index (Journal of applied clinical medical physics · 2026Article
- Multi-modal direct LINAC parameter prediction for pancreatic VMAT: An optimization-free approach.Medical physics · 2026Article
- Development and validation of a DICOM-based prediction model for instantaneous dose rate and delivery time in VMAT.Radiological physics and technology · 2026Article
- Impact of radiotherapy timing on survival and radiotoxicity outcomes in localized prostate cancer: a retrospective cohort study.La Radiologia medica · 2026Article
- Dosimetric and clinical validation of a high-density bolus for superficial skin tumors treated with radiotherapy.Journal of applied clinical medical physics · 2026Article
- Morbidity, Recurrence and Survival Following Pelvic Exenteration for Gynaecological Malignancies: A Retrospective, Single-Centre Study.Journal of clinical medicine · 2026Article
- Revisiting Radiotherapy for Hidradenitis Suppurativa: Clinical Outcomes, Safety, and Optimization Strategies: A Systematic Review.Journal of clinical medicine · 2026Review
- An X-ray and γ-ray combination strategy to exploit steep dose gradients for improved prostate cancer radiotherapy: A dosimetric comparison of Taichi Pro and Halcyon.Journal of applied clinical medical physics · 2026Article
- Evaluation of dose rate and gantry speed variations in volumetric modulated Arc therapy optimization algorithms for a modern linear accelerator.Radiological physics and technology · 2026Article
- Research on real-time detection of radiotherapy setup errors and intelligent quality control methods based on artificial intelligence and big data.Frontiers in oncology · 2026Article
- Evaluation of an acrylic acid hydrogel dosimeter for 3-D dose verification in radiotherapy using MRI.PloS one · 2026Article
- Ferroptosis and Radiotherapy in Lung Cancer.Cells · 2025Review
- Pilot evaluation of Mepitel Film and StrataXRT for the prophylaxis of radiation dermatitis in Chinese breast cancer patients undergoing adjuvant radiotherapy in Hong Kong.Asia-Pacific journal of oncology nursing · 2025Article
- Evaluating the trade-off between plan complexity, dosimetric accuracy, and treatment efficiency: Role of aperture shape controller settings in HyperArc for intracranial oligometastases.Precision radiation oncology · 2025Article
- A few-shot u-net learning framework for fast and accurate three-dimensional dose prediction in radiotherapy.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2025Article
- Hypofractionation Utilisation in Radiation Therapy: A Regional Department Evaluation.Journal of medical radiation sciences · 2025Article
- The Role of Brachytherapy in the Management of Oral Squamous Cell Carcinoma: A Systematic Review.Journal of clinical medicine · 2025Review
- Recent Progress of Nanomedicine for the Synergetic Treatment of Radiotherapy (RT) and Photothermal Treatment (PTT).Cancers · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modern conformal radiation therapy using techniques such as modulation, image guidance and motion management have changed the face of radiotherapy today offering superior conformity, efficiency, and reproducibility to clinics worldwide. This review assesses the impact of these advanced radiotherapy techniques on patient toxicity and survival rates reported from January 2017 to September 2020. The main aims are to establish if dosimetric and efficiency gains correlate with improved survival and reduced toxicities and to answer the question 'What is the clinical evidence for the most effective implementation of VMAT?'. Compared with 3DCRT, improvements have been reported with VMAT in prostate, locally advanced cervical carcinoma and various head and neck applications, leading to the shift in technology to VMAT. Other sites such as thoracic neoplasms and nasopharyngeal carcinomas have observed some improvement with VMAT although not in line with improved dosimetric measures, and the burden of toxicity and the incidence of cancer related deaths remain high, signaling the need to further mitigate toxicity and increase survival. As technological advancement continues, large randomised long-term clinical trials are required to determine the way-forward and offer site-specific recommendations. These studies are usually expensive and time consuming, therefore utilising pooled real-world data in a prospective nature can be an alternative solution to comprehensively assess the efficacy of modern radiotherapy techniques.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.