ArticleeLife2022
Spontaneous neuronal oscillations in the human insula are hierarchically organized traveling waves.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Hidden Spirals Reveal the Neurocomputational Mechanisms of Traveling Waves in Human Memory.bioRxiv : the preprint server for biology · 2026Article
- Planar, spiral, and concentric traveling waves distinguish behavioral states in human memory.Nature communications · 2026Article
- Spontaneous Oscillatory Activity in Episodic Timing: An EEG Replication Study and Its Limitations.eNeuro · 2026Article
- Neural Dynamics of Social Cognition: A Single-Trial Computational Analysis of Learning Under Uncertainty.Human brain mapping · 2026Article
- Article
- A wireless subdural-contained brain-computer interface with 65,536 electrodes and 1,024 channels.Nature electronics · 2025Article
- Perceptual Bias in Motion Discrimination is Related to Asymmetric Interhemispheric Alpha Traveling Waves.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Brain-Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety-Like Behaviors in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Direct interactions between the human insula and hippocampus during memory encoding.Nature neuroscience · 2025Article
- The Neural Correlates of Chewing Gum-A Neuroimaging Review of Its Effects on Brain Activity.Brain sciences · 2025Review
- Stable, chronic in-vivo recordings from a fully wireless subdural-contained 65,536-electrode brain-computer interface device.bioRxiv : the preprint server for biology · 2025Article
- Excessive propagation of right frontal beta oscillations in patients with a history of major depressive disorder.Biomedical engineering letters · 2025Article
- Horizontal cortical connections shape intrinsic traveling waves into feature-selective motifs that regulate perceptual sensitivity.Cell reports · 2024Article
- Return of intracranial beta oscillations and traveling waves with recovery from traumatic brain injury.bioRxiv : the preprint server for biology · 2024Article
- The direction of theta and alpha travelling waves modulates human memory processing.Nature human behaviour · 2024Article
- Human connectome topology directs cortical traveling waves and shapes frequency gradients.Nature communications · 2024Article
- Horizontal cortical connections shape intrinsic traveling waves into feature-selective motifs that regulate perceptual sensitivity.Research square · 2024Article
- Hemodynamic cortical ripples through cyclicity analysis.Network neuroscience (Cambridge, Mass.) · 2024Article
- Decision and response monitoring during working memory are sequentially represented in the human insula.iScience · 2023Article
- Neurophysiological signatures of cortical micro-architecture.Nature communications · 2023Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
The insula plays a fundamental role in a wide range of adaptive human behaviors, but its electrophysiological dynamics are poorly understood. Here, we used human intracranial electroencephalographic recordings to investigate the electrophysiological properties and hierarchical organization of spontaneous neuronal oscillations within the insula. We analyzed the neuronal oscillations of the insula directly and found that rhythms in the theta and beta frequency oscillations are widespread and spontaneously present. These oscillations are largely organized along the anterior-posterior (AP) axis of the insula. Both the left and right insula showed anterior--to-posterior decreasing gradients for the power of oscillations in the beta frequency band. The left insula also showed a posterior-to-anterior decreasing frequency gradient and an anterior-to-posterior decreasing power gradient in the theta frequency band. In addition to measuring the power of these oscillations, we also examined the phase of these signals across simultaneous recording channels and found that the insula oscillations in the theta and beta bands are traveling waves. The strength of the traveling waves in each frequency was positively correlated with the amplitude of each oscillation. However, the theta and beta traveling waves were uncoupled to each other in terms of phase and amplitude, which suggested that insular traveling waves in the theta and beta bands operate independently. Our findings provide new insights into the spatiotemporal dynamics and hierarchical organization of neuronal oscillations within the insula, which, given its rich connectivity with widespread cortical regions, indicates that oscillations and traveling waves have an important role in intrainsular and interinsular communications.
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Registered trials
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