Evidence map›Paper›PMID 35616094›Full record

ArticleRenal failure2022

Diacylglycerol kinase epsilon protects against renal ischemia/reperfusion injury in mice through Krüppel-like factor 15/klotho pathway.

Ziying Wang, Zhuanli Zhou, Yanan Zhang, Fuwen Zuo, Junyao Du, Mingwei Wang, Muchen Hu, Yu Sun, Xiaojie Wang, Min Liu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Ziying WangDepartment of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, China.
Zhuanli ZhouDepartment of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, China.
Yanan ZhangDepartment of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, China.
Fuwen ZuoDepartment of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, China.
Junyao DuDepartment of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, China.
Mingwei WangDepartment of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, China.
Muchen HuDepartment of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, China.
Yu SunDepartment of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, China.
Xiaojie WangDepartment of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, China.
Min LiuDepartment of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, China.
Yan ZhangDepartment of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, China.
Wei TangDepartment of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, China.
Fan YiDepartment of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, China.
Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although recent studies have indicated that mutations in the gene encoding diacylglycerol kinase epsilon (DGKE) result in some proteinuria related hereditary kidney diseases, the DGKE expression pattern in the kidney and its contribution to acute kidney injury (AKI) remain unknown. Therefore, the present study was designed to detect the role of DGKE in mice with AKI. DGKE expression was time-dependently altered in the kidneys of mice with renal ischemia/reperfusion injury (IRI). Compared with wild-type (WT) mice, DGKE- overexpressing mice (

Indexed as

Acute Kidney InjuryDiacylglycerol KinaseReperfusion InjuryAnimalsApoptosisHumansIschemiaKidneyKlotho ProteinsKruppel-Like Transcription FactorsMiceMice, Inbred C57BLDiacylglycerol KinaseKlb protein, mouseKlf15 protein, mouseKlotho ProteinsKruppel-Like Transcription FactorsAcute kidney injurydiacylglycerol kinaseinflammationKlothotubular cell death

Identifiers

PMID35616094
PMCPMC9154760
OpenAlexW4281572538

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.