Evidence map›Paper›PMID 35615991›Full record

ArticleJournal of applied clinical medical physics2022

Technical note: Institutional solution of clinical cine MRI for tumor motion evaluation in radiotherapy.

Taeho Kim, Yu Wu, Zhen Ji, H Michael Gach, Nels Knutson, Stacie Mackey, Matthew Schmidt

Open access · goldAbstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Taeho KimDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.
Yu WuDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.
Zhen JiDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.
H Michael GachDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.
Nels KnutsonDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.
Stacie MackeyDepartment of Radiation Oncology, Barnes Jewish Hospital, St. Louis, Missouri.
Matthew SchmidtDepartment of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.
Washington University in St. Louis · USBarnes-Jewish Hospital · US

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI AIMEE S JAMES · 2001 to 2026
$128.0M
Novel imaging and treatment technologies for image-guided noninvasive stereotactic cardiac radiosurgeryR01HL148210 · NHLBI · WASHINGTON UNIVERSITY · PI GACH, H MICHAEL, YANG, DESHAN · 2019 to 2022
$1.7M
NCI NIH HHS P30 CA091842NHLBI NIH HHS R01 HL148210NIH HHS
6 · The paper itself

Abstract

purposeSince 4D-MRI is inadequate to capture dynamic respiratory variations, real-time cinematographic (cine) MRI is actively used in MR-guided radiotherapy (MRgRT) for tumor motion evaluation, delineation, and tracking. However, most radiotherapy imaging platforms do not support the format of cine MRI from clinical MRI systems. This study developed an institutional solution of clinical cine MRI for tumor motion evaluation in radiotherapy applications.

methodsCine MRI manipulation software (called Cine Viewer) was developed within a commercial Treatment Planning System (TPS). It consists of (1) single/orthogonal viewers, (2) display controllers, (3) measurement grids/markers, and (4) manual contouring tools.

resultsThe institutional solution of clinical cine MRI incorporated with radiotherapy application was assessed through case presentations (liver cancer). Cine Viewer loaded cine MRIs from 1.5T Philips Ingenia MRI, handling MRI DICOM format. The measurement grids and markers were used to quantify the displacement of anatomical structures in addition to the tumor. The contouring tool was utilized to localize the tumor and surrogates on the designated frame. The stacks of the contours were exhibited to present the ranges of tumor and surrogate motions. For example, the stacks of the tumor contours from case-1 were used to determine the ranges of tumor motions (∼8.17 mm on the x-direction [AP-direction] and ∼14 mm on the y-direction [SI-direction]). In addition, the patterns of the displacement of the contours over frames were analyzed and reported using in-house software. In the case-1 review, the tumor was displaced from +146.0 mm on the x-direction and +125.0 mm on the y-direction from the ROI of the abdominal surface.

conclusionWe demonstrated the institutional solution of clinical cine MRI in radiotherapy. The proposed tools can streamline the utilization of cine MRI for tumor motion evaluation using Eclipse for treatment planning.

Indexed as

Liver NeoplasmsMagnetic Resonance Imaging, CineHumansMagnetic Resonance ImagingMotionRespirationcine MRIEclipsetumor motion correlationtumor motion evaluation

Identifiers

PMID35615991
PMCPMC9278668
OpenAlexW4281569862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.