Evidence map›Paper›PMID 35615927›Full record

ArticleHaematologica2022

The successful use of eculizumab for treatment of thrombotic microangiopathy in pediatric acute SARSCoV2 infection and multisystem inflammatory syndrome in children.

Tarun Aurora, Noel Joseph, Senthil Velan Bhoopalan, Miguela A Caniza, Tim Flerlage, Saad Ghafoor, Jane Hankins, Diego R Hijano, Rohith Jesudas, Justin Kirkham and 4 more

Open access · goldAbstract read
In one paragraph

Article in Haematologica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Treatment of multisystem inflammatory syndrome in children.World journal of pediatrics : WJP · 2024
    Review
  5. Observational
  6. The Rationale of Complement Blockade of the MCPInternational journal of molecular sciences · 2023
    Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Tarun AuroraDepartment of Clinical Education, St Jude Children's Research Hospital, Memphis, TN.
Noel JosephDepartment of Pediatrics, Clinical Education, University of Tennessee Health Science Center, Memphis, TN.
Senthil Velan BhoopalanDepartment of Hematology, St Jude Children's Research Hospital, Memphis, TN.
Miguela A CanizaDepartment of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN; Department of Global Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN.
Tim FlerlageDepartment of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN.
Saad GhafoorDepartment of Pediatric Medicine, Division of Critical Care, St Jude Children's Research Hospital, Memphis, TN.
Jane HankinsDepartment of Hematology, St Jude Children's Research Hospital, Memphis, TN.
Diego R HijanoDepartment of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN.
Rohith JesudasDepartment of Hematology, St Jude Children's Research Hospital, Memphis, TN.
Justin KirkhamDepartment of Clinical Education, St Jude Children's Research Hospital, Memphis, TN.
Hugo MartinezDepartment of Pediatrics, Division of Cardiology, University of Tennessee Health Science Center, Memphis, TN.
Gabriela Maron AlfaroDepartment of Infectious Diseases, St Jude Children's Research Hospital, Memphis, TN.
Akshay SharmaDepartment of Bone Marrow Transplantation and Cellular Therapy, St Jude Children's Research Hospital, Memphis, TN.
Melissa HinesDepartment of Pediatric Medicine, Division of Critical Care, St Jude Children's Research Hospital, Memphis, TN. melissa.hines@stjude.org.
St. Jude Children's Research Hospital · USUniversity of Tennessee Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19COVID-19 Drug TreatmentInfectionsThrombotic MicroangiopathiesAntibodies, Monoclonal, HumanizedChildComplement Inactivating AgentsHumansRNA, ViralSARS-CoV-2Systemic Inflammatory Response SyndromeAntibodies, Monoclonal, HumanizedComplement Inactivating AgentseculizumabRNA, Viral

Identifiers

PMID35615927
PMCPMC9521228
OpenAlexW4281566300

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.