Evidence map›Paper›PMID 35615873›Full record

ArticleJournal of neurotrauma2022

Effect of Player Position on Serum Biomarkers during Participation in a Season of Collegiate Football.

Linda Papa, Alexa E Walter, James R Wilkes, Hunter S Clonts, Brian Johnson, Semyon M Slobounov

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurotrauma, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Linda PapaDepartment of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, USA.
Alexa E WalterDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
James R WilkesDepartment of Kinesiology, Pennsylvania State University, University Park, Pennsylvania, USA.
Hunter S ClontsDepartment of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, USA.
Brian JohnsonDepartment of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Semyon M SlobounovDepartment of Kinesiology, Pennsylvania State University, University Park, Pennsylvania, USA.
Orlando Regional Medical Center · USPennsylvania State University · USThe University of Texas Southwestern Medical Center · USUniversity of Pennsylvania · US

Funding

Biomarkers of Mild and Moderate Traumatic Brain InjuryR01NS057676 · NINDS · ORLANDO REGIONAL HEALTHCARE SYSTEM, INC. · PI PAPA, LINDA · 2008 to 2022
$5.8M
NINDS NIH HHS R01 NS057676
6 · The paper itself

Abstract

This prospective cohort study examined the relationship between a panel of four serum proteomic biomarkers (glial fibrillary acidic protein [GFAP], ubiquitin C-terminal hydrolase-L1 [UCH-L1], total Tau, and neurofilament light chain polypeptide [NF-L]) in 52 players from two different cohorts of male collegiate student football athletes from two different competitive seasons of Division I National Collegiate Athletic Association Football Bowl Subdivision. This study evaluated changes in biomarker concentrations (as indicators of brain injury) over the course of the playing season (pre- and post-season) and also assessed biomarker concentrations by player position using two different published classification systems. Player positions were divided into: 1) speed (quarterbacks, running backs, halfbacks, fullbacks, wide receivers, tight ends, defensive backs, safety, and linebackers) versus non-speed (offensive and defensive linemen), and 2) "Profile 1" (low frequency/high strain magnitudes positions including quarterbacks, wide receivers, and defensive backs), "Profile 2" (mid-range impact frequency and strain positions including linebackers, running backs, and tight ends), and "Profile 3" (high frequency/low strains positions including defensive and offensive linemen). There were significant increases in GFAP 39.3 to 45.6 pg/mL and NF-L 3.5 to 5.4 pg/mL over the course of the season (

Indexed as

FootballBiomarkersGlial Fibrillary Acidic ProteinHumansMaleProspective StudiesProteomicsSeasonsUbiquitin ThiolesteraseBiomarkersGlial Fibrillary Acidic ProteinUbiquitin ThiolesteraseathletesbiomarkersconcussionfootballGFAPmild traumatic brain injuryneurofilamentproteomicssportssubconcussionTauUCH-L1

Identifiers

PMID35615873
PMCPMC9529311
OpenAlexW4281559410

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.