Evidence map›Paper›PMID 35615774›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2022

Month of birth and the risk of developing type 1 diabetes among children in the Swedish national Better Diabetes Diagnosis Study.

Emma Hedlund, Johnny Ludvigsson, Helena Elding Larsson, Gun Forsander, Sten Ivarsson, Claude Marcus, Ulf Samuelsson, Martina Persson, Annelie Carlsson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Emma HedlundDepartment of Clinical Sciences Lund, Lund University, Lund, Sweden.ORCID 0000-0001-7707-4540
Johnny LudvigssonCrown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden.ORCID 0000-0003-1695-5234
Helena Elding LarssonDepartment of Clinical Sciences, Malmö, Lund University, CRC, Malmö, Sweden.
Gun ForsanderThe Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden.
Sten IvarssonDepartment of Clinical Sciences, Malmö, Lund University, CRC, Malmö, Sweden.
Claude MarcusDivision of Pediatrics, Department of Clinical Science Intervention and Technology, Karolinska Institute, Stockholm, Sweden.
Ulf SamuelssonCrown Princess Victoria Children's Hospital, Linköping University Hospital, Linköping, Sweden.
Martina PerssonDepartment of Medicine, Clinical Epidemiology, Karolinska Institute, Stockholm, Sweden.
Annelie CarlssonDepartment of Clinical Sciences Lund, Lund University, Lund, Sweden.ORCID 0000-0002-5608-3437
Lund University · SEKarolinska Institutet · SELinköping University · SESahlgrenska University Hospital · SE

Funding

BarndiabetesfondenRegion Skåne
6 · The paper itself

Abstract

aimPrevious studies have reported an association between month of birth and incidence of type 1 diabetes. Using population-based data, including almost all newly diagnosed children with type 1 diabetes in Sweden, we tested whether month of birth influences the risk of type 1 diabetes.

methodsFor 8761 children diagnosed with type 1 diabetes between May 2005 and December 2016 in the Better Diabetes Diagnosis study, month of birth, sex and age were compared. Human leucocyte antigen (HLA) genotype and autoantibodies at diagnosis were analysed for a subset of the cohort (n = 3647). Comparisons with the general population used data from Statistics Sweden.

resultsWe found no association between month of birth or season and the incidence of type 1 diabetes in the cohort as a whole. However, boys diagnosed before 5 years were more often born in May (p = 0.004). We found no correlation between month of birth and HLA or antibodies.

conclusionIn this large nationwide study, the impact of month of birth on type 1 diabetes diagnosis was weak, except for boys diagnosed before 5 years of age, who were more likely born in May. This may suggest different triggers for different subgroups of patients with type 1 diabetes.

Indexed as

Diabetes Mellitus, Type 1AutoantibodiesChildFemaleGenotypeHLA-DQ AntigensHumansMaleSwedenAutoantibodiesHLA-DQ Antigensautoantibodiesbirth patternHLA-DQ allelesseasonalitytype 1 diabetes

Identifiers

PMID35615774
PMCPMC9795915
OpenAlexW4281553885

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.