ArticleFrontiers in human neuroscience2022
Fatigue Across the Lifespan in Men and Women: State vs. Trait.
Article in Frontiers in human neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Mental fatigue and brain activation using prolonged task-based fMRI: a systematic review on time-on-task and sequential task paradigms.Experimental brain research · 2026Pooled it
- Cognitive fatigue is related to reduced cerebral perfusion and sustained attention in patients with post COVID-19 condition: An fMRI study.Neuroimage. Reports · 2026Article
- Towards a domain-general mechanistic model of fatigue: application to Functional Neurological Disorder.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Review
- Temporal Robustness of Mental Fatigue Susceptibility: A One-Year Follow-up Study.Sports medicine - open · 2026Article
- Feasibility of Privacy-Preserving LiDAR-Based Continuous Gait and Activity Monitoring in Three People with Multiple Sclerosis: A Technical Proof-of-Concept Case Study.Sensors (Basel, Switzerland) · 2026Article
- Disparities in fatigue levels and dietary habits between men and women with inflammatory bowel disease: a comparative analysis with a control cohort.European journal of nutrition · 2026Article
- Toward Measuring Cognitive Endurance Capacity: A Proof-of-Principle Study in a Healthy Population.Journal of occupational rehabilitation · 2026Article
- The differential effect of chronological age and brain age on cognitive fatigue: new metrics, new insights.Journal of neurology · 2026Article
- Exploring the potential effects of different frequencies of flashing light stimulation on alleviating mental fatigue: a behavioral and EEG study.Frontiers in human neuroscience · 2026Article
- Brain-predicted age difference is associated with the progression of subthreshold depression: evidence from the UK Biobank.Psychoradiology · 2026Article
- Fatigue: a common but poorly understood symptom in neurological and non-neurological diseases.Nature reviews. Neurology · 2025Review
- Individual training prescribed by heart rate variability, heart rate and well-being scores in experienced cyclists.Scientific reports · 2025Article
- Fatigue of Cancer is Distinctly Different than the Fatigue of Chronic Kidney Disease.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Psychometric validity of the Perceived Home Management Hassles Scale.Scientific reports · 2025Article
- Gender Differences in the Relationship Between Fatigue, Different Types of Physical Activity, Postural Changes, and Sleep Quality in University Students-Part II Analyses from a Cross-Sectional Study.Journal of functional morphology and kinesiology · 2025Article
- Neuroimaging markers of cognitive fatigue in individuals with post-acute sequelae of SARS-CoV-2 infection.Brain and cognition · 2025Article
- Mapping the brain's fatigue network: a transdiagnostic systematic review and meta-analysis on functional correlates of mental fatigue.Brain communications · 2025Review
- Fatigue and its correlation with anxiety and depression in patients with multiple sclerosis in China.Frontiers in neurology · 2025Article
- Clinical and Physiological Variables in Patients with Post-COVID-19 Condition and Persistent Fatigue.Journal of clinical medicine · 2024Article
- The Influence of Changes in Daily Life Habits and Well-Being on Fatigue Level During COVID-19 Pandemic.Psychologica Belgica · 2024Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Objective: Fatigue is commonly thought to worsen with age, but the literature is mixed: some studies show that older individuals experience more fatigue, others report the reverse. Some inconsistencies in the literature may be related to gender differences in fatigue while others may be due to differences in the instruments used to study fatigue, since the correlation between state (in the moment) and trait (over an extended period of time) measures of fatigue has been shown to be weak. The purpose of the current study was to examine both state and trait fatigue across age and gender using neuroimaging and self-report data. Methods: We investigated the effects of age and gender in 43 healthy individuals on self-reported fatigue using the Modified Fatigue Impact Scale (MFIS), a measure of trait fatigue. We also conducted fMRI scans on these individuals and collected self-reported measures of state fatigue using the visual analog scale of fatigue (VAS-F) during a fatiguing task. Results: There was no correlation between age and total MFIS score (trait fatigue) ( Conclusion: Older individuals reported less fatigue during task performance (state measures). The neuroimaging data indicate that the role of middle frontal areas change across age: younger individuals may use these areas to combat fatigue, but this is not the case with older individuals. Moreover, these results may suggest greater resilience in females than males when faced with a fatiguing task.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.