ArticleFrontiers in endocrinology2022
Nightshift Work and Nighttime Eating Are Associated With Higher Insulin and Leptin Levels in Hospital Nurses.
Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 17 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 5 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- A Systematic Review of Nutrition Interventions for Shift Workers, With Subgroup Analysis of First Responder Populations.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026Pooled it
- Long-term night shift work and cardiometabolic health in healthcare workers: a review of mechanisms and precision intervention strategies.Frontiers in public health · 2026Pooled it
- Shift work and metabolic dysfunction-associated steatotic liver disease: a systematic review of observational studies.International archives of occupational and environmental health · 2025Pooled it
- Pooled it
- Current evidence and future perspectives in the exploration of sleep-related eating disorder-a systematic literature review.Frontiers in psychiatry · 2024Pooled it
- The nutritional and metabolic impact of night shift work in a real-world setting.Npj biological timing and sleep · 2026Article
- Deep learning-based physiological risk stratification in night-shift hospital workers.Scientific reports · 2026Article
- Night-eating syndrome is associated with food consumption frequency among Chinese college students.Scientific reports · 2026Article
- Article
- Shift work sleep disorder in nurses: a concept analysis.BMC nursing · 2025Review
- Association between shift work and insulin resistance in women: Implications for metabolic health.PloS one · 2025Article
- Association between work shifts, occupational stress, and abdominal obesity in female workers in Southern Brazil.Frontiers in public health · 2025Article
- Circadian de(regulation) in physiology: implications for disease and treatment.Genes & development · 2024Review
- Association of Shift Work, Sociodemographic Variables and Healthy Habits with Obesity Scales.Life (Basel, Switzerland) · 2024Article
- Circadian rhythm in cardiovascular diseases: a bibliometric analysis of the past, present, and future.European journal of medical research · 2023Review
- Chronic environmental circadian disruption increases atherosclerosis and dyslipidemia in female, but not male,Frontiers in physiology · 2023Article
- The Impact of Job-Demand-Control-Support on Leptin and Ghrelin as Biomarkers of Stress in Emergency Healthcare Workers.Nutrients · 2022Observational
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Background: Circadian misalignment between behaviors such as feeding and endogenous circadian rhythms, particularly in the context of shiftwork, is associated with poorer cardiometabolic health. We examined whether insulin and leptin levels differ between dayshift versus nightshift nurses, as well as explored whether the timing of food intake modulates these effects in nightshift workers. Methods: Female nurses (N=18; 8 dayshift and 10 nightshift) completed daily diet records for 8 consecutive days. The nurses then completed a 24-h inpatient stay, during which blood specimens were collected every 3 h (beginning at 09:00) and meals were consumed at regular 3-h intervals (09:00, 12:00, 15:00, and 18:00). Specimens were analyzed for insulin and leptin levels, and generalized additive models were used to examine differences in mean insulin and leptin levels. Results: Mean insulin and leptin levels were higher in nightshift nurses by 11.6 ± 3.8 mU/L (p=0.003) and 7.4 ± 3.4 ng/ml (p=0.03), respectively, compared to dayshift nurses. In an exploratory subgroup analysis of nightshift nurses, predominately eating at night (21:00 - 06:00) was associated with significantly higher insulin and leptin levels than consuming most calories during the daytime (06:00 - 21:00). Conclusions: In our study of hospital nurses, working the nightshift was associated with higher insulin and leptin levels, and these effects were driven by eating predominately at night. We conclude that although nightshift work may raise insulin and leptin levels, eating during the daytime may attenuate some of the negative effects of nightshift work on metabolic health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.