ArticleJournal of immunology research2022
Associations between Autoimmunity and Depression: Serum IL-6 and IL-17 Have Directly Impact on the HAMD Scores in Patients with First-Episode Depressive Disorder.
Article in Journal of immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Altered Cytokine Levels in the First Episode of Major Depression and in Antidepressant-Naïve Patients: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Activation of the interleukin-23/Th17 axis in major depression: a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2025Pooled it
- Effects of mind-body therapies on depression among adolescents: a systematic review and network meta-analysis.Frontiers in public health · 2024Pooled it
- Effectiveness of yoga for major depressive disorder: A systematic review and meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Inflammation is associated with altered functional connectivity of the cingulate cortex in individuals with subthreshold depression.PLOS digital health · 2026Article
- The association between spatiotemporal coupling of default mode network and behaviors is specifically modulated by peripheral inflammation in major depressive disorder.BMC psychiatry · 2026Article
- Muribaculum intestinale alleviates depressive-like behaviors by inhibiting Th17 cell differentiation and M1 microglia polarization.Microbiome · 2026Article
- Diagnostic Accuracy of Interleukin-17A for Internal Derangements of Temporomandibular Joints in Patients with Spondyloarthritis.Biomedicines · 2026Article
- UPLC-Q-TOF-MS, Network Pharmacology and Molecular Docking to Reveal the Antidepressant Mechanism of the Different Components of Medicinal and Edible Lilies (Combinatorial chemistry & high throughput screening · 2026Article
- Serum inflammatory cytokines in the progression of depression.Frontiers in immunology · 2026Review
- Blocking IL-17A inhibits methamphetamine-induced hyperlocomotion and conditioned place preference and prevents methamphetamine abstinence-induced depression-like behaviors in mice.Neuropharmacology · 2025Article
- Microglia reactivity is brain region and sex specific in the context of chronic stress.Scientific reports · 2025Article
- The role of interleukin-17 in neurological disorders.Animal cells and systems · 2025Review
- Serum TNFα and IL-17A levels may predict increased depressive symptoms: findings from the Shika Study cohort project in Japan.BioPsychoSocial medicine · 2024Article
- Decoding the inflammatory signature of the major depressive episode: insights from peripheral immunophenotyping in active and remitted condition, a case-control study.Translational psychiatry · 2024Article
- Review
- Associations between serum estradiol and IL-6/sIL-6R/sgp130 complex in female patients with major depressive disorder.BMC psychiatry · 2023Article
- Deiodinase Types 1 and 3 and Proinflammatory Cytokine Values May Discriminate Depressive Disorder Patients from Healthy Controls.Journal of clinical medicine · 2023Article
- The role of inflammatory biomarkers in the association between rheumatoid arthritis and depression: a Mendelian randomization study.Inflammopharmacology · 2023Article
- Advances in the study of IL-17 in neurological diseases and mental disorders.Frontiers in neurology · 2023Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The study is aimed at evaluating the immune-activation state before and after treatment in patients with first-episode depressive disorder (FDD) with evaluating the ILs and CRP levels and further clarifying the association between autoimmunity and the etiology and pathogenesis of FDD. Methods: We designed a case-control study. FDD patients and healthy subjects were enrolled in the FDD group and control group. Serum IL-6, IL-17, and CRP were measured before and after selective serotonin reuptake inhibitor (SSRI) therapy, as well as Hamilton rating scale for depression (HAMD) and life event scale (LES) scores. The correlations between IL-6 and IL-17 and HAMD and LES scores were analysed, and multiple linear regression analysis was performed for HAMD score. Results: 40 FDD patients and 40 healthy subjects were included in the FDD and control group from October 2009 to September 2012. Before treatment, the IL-6 (28.99 ± 5.51, Conclusion: The autoimmunity status was overactivated in FDD patients, and serum IL-6 and IL-17 levels had direct impact on the HAMD score. Patients who experienced more negative life events had higher activation level of autoimmunity status and HAMD scores, and serum IL-6 and IL-17 levels can be decreased by SSRI treatment.
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