ArticleFrontiers in psychiatry2022
Alterations of Static and Dynamic Functional Connectivity of the Nucleus Accumbens in Patients With Major Depressive Disorder.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Resting-state network alterations in depression: a comprehensive meta-analysis of functional connectivity.Psychological medicine · 2025Pooled it
- The ventral/anterior hippocampus as a central hub for stress-related dopaminergic circuit dysfunction in psychiatric disorders.Molecular psychiatry · 2026Review
- The role of the subcortical structures in subthreshold depression: evidence from static and dynamic functional connectivity.Brain structure & function · 2026Article
- Cue-Dependent Fear Learning Drives Nucleus Accumbens Spine Plasticity.bioRxiv : the preprint server for biology · 2026Article
- Socioeconomic Status Is Associated With Reward Processing, Interleukin 1β, Striatal Connectivity, and Antidepressant Outcomes in Individuals With Major Depressive Disorder: A CAN-BIND-1 Report.Biological psychiatry global open science · 2026Article
- Functional connectivity of the nucleus accumbens and the amygdala in offspring of parents with bipolar or major depressive disorder.European archives of psychiatry and clinical neuroscience · 2026Article
- Reward circuit function and treatment outcome following vALIC deep brain stimulation in treatment-resistant depression.Molecular psychiatry · 2026Article
- Deep brain stimulation modulates directional limbic connectivity in major depressive disorder.Psychological medicine · 2025Article
- Resting-state fMRI reveals altered functional connectivity associated with resilience and susceptibility to chronic social defeat stress in mouse brain.Molecular psychiatry · 2025Article
- Abnormal static and dynamic functional connectivity of striatal subregions in patients with obsessive-compulsive disorder.Frontiers in psychiatry · 2025Article
- Aberrant functional connectivity of the dorsolateral prefrontal cortex-nucleus accumbens during naturalistic stimulation in adolescent major depressive disorder.Frontiers in psychiatry · 2025Article
- Modulation of functional network co-activation pattern dynamics following ketamine treatment in major depression.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Anhedonia is associated with higher functional connectivity between the nucleus accumbens and paraventricular nucleus of thalamus.Journal of affective disorders · 2024Article
- Modulation of habenular and nucleus accumbens functional connectivity by ketamine in major depression.Brain and behavior · 2024Article
- Dynamic network characteristics of adolescents with major depressive disorder: Attention network mediates the association between anhedonia and attentional deficit.Human brain mapping · 2023Article
- Abnormal functional connectivity of the nucleus accumbens subregions mediates the association between anhedonia and major depressive disorder.BMC psychiatry · 2023Article
- The Static and dynamic functional connectivity characteristics of the left temporoparietal junction region in schizophrenia patients with auditory verbal hallucinations during low-frequency rTMS treatment.Frontiers in psychiatry · 2023Article
- [Abnormal functional connectivity and structure-function coupling of the nucleus accumbens in patients with major depressive disorder].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciencesArticle
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Major depressive disorder (MDD) is associated with dysfunction of the reward system. As an important node in the reward system, the resting-state functional connectivity of the nucleus accumbens (NAc) is related to the etiology of MDD. However, an increasing number of recent studies propose that brain activity is dynamic over time, no study to date has examined whether the NAc dynamic functional connectivity (DFC) is changed in patients with MDD. Moreover, few studies have examined the impact of the clinical characteristics of patients with MDD. Methods: A total of 220 MDD patients and 159 healthy controls (HCs), group-matched for age, sex, and education level, underwent resting-state functional magnetic resonance imagining (rs-fMRI) scans. Seed-based resting-state functional connectivity (RSFC) and DFC of the NAc were conducted. Two sample Results: Compared with the HCs, MDD patients show reduced the NAc-based RSFC with the dorsolateral prefrontal cortex (DLPFC), hippocampus, middle temporal gyrus (MTG), inferior temporal gyrus (ITG), precuneus, and insula, and patients with MDD show reduced the NAc-based DFC with the DLPFC, ventromedial prefrontal cortex (VMPFC), ventrolateral prefrontal cortex (VLPFC), MTG, ITG, and insula. MDD severity was associated with RSFC between the NAc and precentral gyrus ( Conclusion: This study demonstrates abnormal RSFC and DFC between the NAc and distributed cerebral regions in MDD patients, characterized by decreased RSFC and DFC of the NAc connecting with the reward, executive, default-mode, and salience network. Our results expand previous descriptions of the NAc RSFC abnormalities in MDD, and the altered RSFC/DFC may reflect the disrupted function of the NAc.
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